The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which induces a high release of pro-inflammatory chemokines and cytokines, leading to severe systemic disorders. Further, evidence has shown that recovered COVID-19 patients still have some symptoms and disorders from COVID-19. Physic...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051059/full |
| _version_ | 1797961499617001472 |
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| author | Tayrine Ordonio Filgueira Paulo Roberto Cavalcanti Carvalho Matheus Santos de Sousa Fernandes Angela Castoldi Angela Castoldi Angela Castoldi Ana Maria Teixeira Renata Bezerra de Albuquerque José Luiz de Lima-Filho José Luiz de Lima-Filho Fabrício Oliveira Souto Fabrício Oliveira Souto Fabrício Oliveira Souto |
| author_facet | Tayrine Ordonio Filgueira Paulo Roberto Cavalcanti Carvalho Matheus Santos de Sousa Fernandes Angela Castoldi Angela Castoldi Angela Castoldi Ana Maria Teixeira Renata Bezerra de Albuquerque José Luiz de Lima-Filho José Luiz de Lima-Filho Fabrício Oliveira Souto Fabrício Oliveira Souto Fabrício Oliveira Souto |
| author_sort | Tayrine Ordonio Filgueira |
| collection | DOAJ |
| description | COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which induces a high release of pro-inflammatory chemokines and cytokines, leading to severe systemic disorders. Further, evidence has shown that recovered COVID-19 patients still have some symptoms and disorders from COVID-19. Physical exercise can have many health benefits. It is known to be a potent regulator of the immune system, which includes frequency, intensity, duration, and supervised by a professional. Given the confinement and social isolation or hospitalization of COVID-19 patients, the population became sedentary or opted for physical exercise at home, assuming the guarantee of the beneficial effects of physical exercise and reducing exposure to SARS-CoV-2. This study aimed to investigate the effects of a supervised exercise protocol and a home-based unsupervised exercise protocol on chemokine and cytokine serum levels in recovered COVID-19 patients. This study was a prospective, parallel, two-arm clinical trial. Twenty-four patients who had moderate to severe COVID-19 concluded the intervention protocols of this study. Participants were submitted to either supervised exercise protocol at the Clinical Hospital of the Federal University of Pernambuco or home-based unsupervised exercise for 12 weeks. We analyzed serum levels of chemokines (CXCL8/IL-8, CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10) and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, and IFN-γ). Before the interventions, no significant differences were observed in the serum levels of chemokines and cytokines between the supervised and home-based unsupervised exercise groups. The CXCL8/IL-8 (p = 0.04), CCL2/MCP-1 (p = 0.03), and IFN-γ (p = 0.004) levels decreased after 12 weeks of supervised exercise. In parallel, an increase in IL-2 (p = 0.02), IL-6 (p = 0.03), IL-4 (p = 0.006), and IL-10 (p = 0.04) was observed after the supervised protocol compared to pre-intervention levels. No significant differences in all the chemokines and cytokines were found after 12 weeks of the home-based unsupervised exercise protocol. Given the results, the present study observed that supervised exercise was able to modulate the immune response in individuals with post-COVID-19, suggesting that supervised exercise can mitigate the inflammatory process associated with COVID-19 and its disorders.Clinical trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-7z3kxjk, identifier U1111-1272-4730. |
| first_indexed | 2024-04-11T00:59:08Z |
| format | Article |
| id | doaj.art-bf5b50653d814eeea2277e3aa6fe8168 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T00:59:08Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bf5b50653d814eeea2277e3aa6fe81682023-01-04T19:39:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10510591051059The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patientsTayrine Ordonio Filgueira0Paulo Roberto Cavalcanti Carvalho1Matheus Santos de Sousa Fernandes2Angela Castoldi3Angela Castoldi4Angela Castoldi5Ana Maria Teixeira6Renata Bezerra de Albuquerque7José Luiz de Lima-Filho8José Luiz de Lima-Filho9Fabrício Oliveira Souto10Fabrício Oliveira Souto11Fabrício Oliveira Souto12Postgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, BrazilPostgraduate Program in Surgery, Center for Medical Sciences, Federal University of Pernambuco, Recife, BrazilPostgraduate Program in Neuropsychiatry and Behavioral Sciences, Center of Medical Sciences, Federal University of Pernambuco, Recife, BrazilPostgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, BrazilKeizo Asami Institute, Federal University of Pernambuco, Recife, BrazilLife Sciences Center, Agreste Academic Center, Federal University of Pernambuco, Caruaru, BrazilFaculty of Sport Sciences and Physical Education, Research Center for Sport and Physical Activity, University of Coimbra, Coimbra, PortugalPostgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, BrazilPostgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, BrazilKeizo Asami Institute, Federal University of Pernambuco, Recife, BrazilPostgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, BrazilKeizo Asami Institute, Federal University of Pernambuco, Recife, BrazilLife Sciences Center, Agreste Academic Center, Federal University of Pernambuco, Caruaru, BrazilCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which induces a high release of pro-inflammatory chemokines and cytokines, leading to severe systemic disorders. Further, evidence has shown that recovered COVID-19 patients still have some symptoms and disorders from COVID-19. Physical exercise can have many health benefits. It is known to be a potent regulator of the immune system, which includes frequency, intensity, duration, and supervised by a professional. Given the confinement and social isolation or hospitalization of COVID-19 patients, the population became sedentary or opted for physical exercise at home, assuming the guarantee of the beneficial effects of physical exercise and reducing exposure to SARS-CoV-2. This study aimed to investigate the effects of a supervised exercise protocol and a home-based unsupervised exercise protocol on chemokine and cytokine serum levels in recovered COVID-19 patients. This study was a prospective, parallel, two-arm clinical trial. Twenty-four patients who had moderate to severe COVID-19 concluded the intervention protocols of this study. Participants were submitted to either supervised exercise protocol at the Clinical Hospital of the Federal University of Pernambuco or home-based unsupervised exercise for 12 weeks. We analyzed serum levels of chemokines (CXCL8/IL-8, CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10) and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, and IFN-γ). Before the interventions, no significant differences were observed in the serum levels of chemokines and cytokines between the supervised and home-based unsupervised exercise groups. The CXCL8/IL-8 (p = 0.04), CCL2/MCP-1 (p = 0.03), and IFN-γ (p = 0.004) levels decreased after 12 weeks of supervised exercise. In parallel, an increase in IL-2 (p = 0.02), IL-6 (p = 0.03), IL-4 (p = 0.006), and IL-10 (p = 0.04) was observed after the supervised protocol compared to pre-intervention levels. No significant differences in all the chemokines and cytokines were found after 12 weeks of the home-based unsupervised exercise protocol. Given the results, the present study observed that supervised exercise was able to modulate the immune response in individuals with post-COVID-19, suggesting that supervised exercise can mitigate the inflammatory process associated with COVID-19 and its disorders.Clinical trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-7z3kxjk, identifier U1111-1272-4730.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051059/fullsupervised exercise protocolhome-based exerciseimmune biomarkerschemokinescytokinesCOVID-19 |
| spellingShingle | Tayrine Ordonio Filgueira Paulo Roberto Cavalcanti Carvalho Matheus Santos de Sousa Fernandes Angela Castoldi Angela Castoldi Angela Castoldi Ana Maria Teixeira Renata Bezerra de Albuquerque José Luiz de Lima-Filho José Luiz de Lima-Filho Fabrício Oliveira Souto Fabrício Oliveira Souto Fabrício Oliveira Souto The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients Frontiers in Immunology supervised exercise protocol home-based exercise immune biomarkers chemokines cytokines COVID-19 |
| title | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients |
| title_full | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients |
| title_fullStr | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients |
| title_full_unstemmed | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients |
| title_short | The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients |
| title_sort | impact of supervised physical exercise on chemokines and cytokines in recovered covid 19 patients |
| topic | supervised exercise protocol home-based exercise immune biomarkers chemokines cytokines COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051059/full |
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