Characterization of Histone Deacetylase Mechanisms in Cancer Development
Over decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of physiological processes. Histone deacetylases (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.700947/full |
| _version_ | 1818647453548675072 |
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| author | Rihan Hai Rihan Hai Liuer He Liuer He Guang Shu Gang Yin |
| author_facet | Rihan Hai Rihan Hai Liuer He Liuer He Guang Shu Gang Yin |
| author_sort | Rihan Hai |
| collection | DOAJ |
| description | Over decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of physiological processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are pivotal epigenetic modulators that regulate dynamic processes in the acetylation of histones at lysine residues, thereby influencing transcription of oncogenes and tumour suppressor genes. Moreover, HDACs mediate the deacetylation process of many nonhistone proteins and thus orchestrate a host of pathological processes, such as tumour pathogenesis. In this review, we elucidate the functions of HDACs in cancer. |
| first_indexed | 2024-12-17T01:02:47Z |
| format | Article |
| id | doaj.art-bf5d2808d0ef4d2f84d10443df09d381 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T01:02:47Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bf5d2808d0ef4d2f84d10443df09d3812022-12-21T22:09:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-07-011110.3389/fonc.2021.700947700947Characterization of Histone Deacetylase Mechanisms in Cancer DevelopmentRihan Hai0Rihan Hai1Liuer He2Liuer He3Guang Shu4Gang Yin5Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, ChinaSchool of Basic Medical Sciences, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, ChinaSchool of Basic Medical Sciences, Central South University, Changsha, ChinaSchool of Basic Medical Sciences, Central South University, Changsha, ChinaDepartment of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, ChinaOver decades of studies, accumulating evidence has suggested that epigenetic dysregulation is a hallmark of tumours. Post-translational modifications of histones are involved in tumour pathogenesis and development mainly by influencing a broad range of physiological processes. Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are pivotal epigenetic modulators that regulate dynamic processes in the acetylation of histones at lysine residues, thereby influencing transcription of oncogenes and tumour suppressor genes. Moreover, HDACs mediate the deacetylation process of many nonhistone proteins and thus orchestrate a host of pathological processes, such as tumour pathogenesis. In this review, we elucidate the functions of HDACs in cancer.https://www.frontiersin.org/articles/10.3389/fonc.2021.700947/fullepigeneticsprotein acetylationhistone deacetylasescancertumorigenesis |
| spellingShingle | Rihan Hai Rihan Hai Liuer He Liuer He Guang Shu Gang Yin Characterization of Histone Deacetylase Mechanisms in Cancer Development Frontiers in Oncology epigenetics protein acetylation histone deacetylases cancer tumorigenesis |
| title | Characterization of Histone Deacetylase Mechanisms in Cancer Development |
| title_full | Characterization of Histone Deacetylase Mechanisms in Cancer Development |
| title_fullStr | Characterization of Histone Deacetylase Mechanisms in Cancer Development |
| title_full_unstemmed | Characterization of Histone Deacetylase Mechanisms in Cancer Development |
| title_short | Characterization of Histone Deacetylase Mechanisms in Cancer Development |
| title_sort | characterization of histone deacetylase mechanisms in cancer development |
| topic | epigenetics protein acetylation histone deacetylases cancer tumorigenesis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.700947/full |
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