Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period
Objective To retrospectively analyze the clinical characteristics of patients with Cushing's syndrome (CS) complicated with perioperative pulmonary embolism (PE). Methods Depending on Chinese Pituitary Disease Registry Network (CPDRN) and Pituitary Tumor Database in Peking Union Medical College...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2021-03-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2293 |
| _version_ | 1819073422810939392 |
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| author | SUN Xu LU Lin FENG Ming ZHU Hui⁃juan YAO Yong WANG Ren⁃zhi |
| author_facet | SUN Xu LU Lin FENG Ming ZHU Hui⁃juan YAO Yong WANG Ren⁃zhi |
| author_sort | SUN Xu |
| collection | DOAJ |
| description | Objective To retrospectively analyze the clinical characteristics of patients with Cushing's syndrome (CS) complicated with perioperative pulmonary embolism (PE). Methods Depending on Chinese Pituitary Disease Registry Network (CPDRN) and Pituitary Tumor Database in Peking Union Medical College Hospital, 20 patients with CS complicated perioperative PE were collected from January 1, 2013 to September 30, 2020, and the clinical manifestations and laboratory examination data of the patients were investigated. The clinical characteristics were compared between ectopic adrenocorticotropic hormone syndrome (EAS) and CS with PE during the perioperative period. In addition, clinical characteristics were also studied in these patients before and after the operation. Results According to etiology, they were divided into CS (7 cases), EAS (9 cases) and adrenal adenoma (4 cases). The course of CS was longer than EAS (t = ⁃ 2.938, P = 0.011). According to the occurrence time of PE, the patients were divided into preoperative PE (13 cases) and postoperative PE (7 cases). The patients with postoperative PE had a lower body mass index (t = 2.427, P = 0.026) and a higher fibrinogen (t = ⁃ 2.162, P = 0.047). The patients with PE before surgery included 5 cases of CS, 5 cases of EAS, and 3 cases of adrenal adenomas, while those who with PE after surgery included 2 cases of CS, 4 cases of EAS, and one case of adrenal adenoma. Among the 7 patients with PE after surgery, 5 cases did not get remission. Compared with preoperative examination, the erythrocyte count (t = ⁃ 2.032, P = 0.042) and hemoglobin (t = 9.807, P = 0.001) were decreased after operation, the prothrombin time (t = ⁃ 2.847, P = 0.047) and international normalized ratio (t = ⁃ 3.059, P = 0.038) were increased after operation. Conclusions Longer course of disease and no remission hypercortisolemia after surgery may be the risk factors for perioperative PE in CS patients. Patients with elevated fibrinogen before surgery and reduced red blood cell count and hemoglobin after surgery should be alert to the risk of PE.
doi：10.3969/j.issn.1672⁃6731.2021.03.009 |
| first_indexed | 2024-12-21T17:53:22Z |
| format | Article |
| id | doaj.art-bf5dcd5ee3b049d5a14b6b8f5668ac7d |
| institution | Directory Open Access Journal |
| issn | 1672-6731 1672-6731 |
| language | English |
| last_indexed | 2024-12-21T17:53:22Z |
| publishDate | 2021-03-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-bf5dcd5ee3b049d5a14b6b8f5668ac7d2022-12-21T18:55:16ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312021-03-01213177184Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative periodSUN Xu0 LU Lin1FENG Ming2 ZHU Hui⁃juan3YAO Yong4WANG Ren⁃zhi5Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Translational Medicine Center of Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Translational Medicine Center of Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Translational Medicine Center of Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaObjective To retrospectively analyze the clinical characteristics of patients with Cushing's syndrome (CS) complicated with perioperative pulmonary embolism (PE). Methods Depending on Chinese Pituitary Disease Registry Network (CPDRN) and Pituitary Tumor Database in Peking Union Medical College Hospital, 20 patients with CS complicated perioperative PE were collected from January 1, 2013 to September 30, 2020, and the clinical manifestations and laboratory examination data of the patients were investigated. The clinical characteristics were compared between ectopic adrenocorticotropic hormone syndrome (EAS) and CS with PE during the perioperative period. In addition, clinical characteristics were also studied in these patients before and after the operation. Results According to etiology, they were divided into CS (7 cases), EAS (9 cases) and adrenal adenoma (4 cases). The course of CS was longer than EAS (t = ⁃ 2.938, P = 0.011). According to the occurrence time of PE, the patients were divided into preoperative PE (13 cases) and postoperative PE (7 cases). The patients with postoperative PE had a lower body mass index (t = 2.427, P = 0.026) and a higher fibrinogen (t = ⁃ 2.162, P = 0.047). The patients with PE before surgery included 5 cases of CS, 5 cases of EAS, and 3 cases of adrenal adenomas, while those who with PE after surgery included 2 cases of CS, 4 cases of EAS, and one case of adrenal adenoma. Among the 7 patients with PE after surgery, 5 cases did not get remission. Compared with preoperative examination, the erythrocyte count (t = ⁃ 2.032, P = 0.042) and hemoglobin (t = 9.807, P = 0.001) were decreased after operation, the prothrombin time (t = ⁃ 2.847, P = 0.047) and international normalized ratio (t = ⁃ 3.059, P = 0.038) were increased after operation. Conclusions Longer course of disease and no remission hypercortisolemia after surgery may be the risk factors for perioperative PE in CS patients. Patients with elevated fibrinogen before surgery and reduced red blood cell count and hemoglobin after surgery should be alert to the risk of PE. doi：10.3969/j.issn.1672⁃6731.2021.03.009http://www.cjcnn.org/index.php/cjcnn/article/view/2293cushing syndromepulmonary embolismacth syndromeectopicperioperative period |
| spellingShingle | SUN Xu LU Lin FENG Ming ZHU Hui⁃juan YAO Yong WANG Ren⁃zhi Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period Chinese Journal of Contemporary Neurology and Neurosurgery cushing syndrome pulmonary embolism acth syndrome ectopic perioperative period |
| title | Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period |
| title_full | Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period |
| title_fullStr | Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period |
| title_full_unstemmed | Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period |
| title_short | Analysis of clinical characteristics of Cushing's syndrome complicated with pulmonary embolism during perioperative period |
| title_sort | analysis of clinical characteristics of cushing s syndrome complicated with pulmonary embolism during perioperative period |
| topic | cushing syndrome pulmonary embolism acth syndrome ectopic perioperative period |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2293 |
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