Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients
IntroductionTo investigate the prognostic value of the consistency between the residual quantitative flow ratio (QFR) and postpercutaneous coronary intervention (PCI) QFR in patients undergoing revascularization.MethodsThis was a single-center, retrospective, observational study. All enrolled patien...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1297218/full |
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| author | Lihua Chen Lihua Chen Lihua Chen Lihua Chen Jiaxin Zhong Jiaxin Zhong Jiaxin Zhong Ruijin Hong Ruijin Hong Ruijin Hong Yuxiang Chen Yuxiang Chen Yuxiang Chen Beilei Li Beilei Li Beilei Li Laicheng Wang Laicheng Wang Laicheng Wang Yuanming Yan Yuanming Yan Yuanming Yan Lianglong Chen Lianglong Chen Lianglong Chen Qin Chen Qin Chen Qin Chen Yukun Luo Yukun Luo Yukun Luo |
| author_facet | Lihua Chen Lihua Chen Lihua Chen Lihua Chen Jiaxin Zhong Jiaxin Zhong Jiaxin Zhong Ruijin Hong Ruijin Hong Ruijin Hong Yuxiang Chen Yuxiang Chen Yuxiang Chen Beilei Li Beilei Li Beilei Li Laicheng Wang Laicheng Wang Laicheng Wang Yuanming Yan Yuanming Yan Yuanming Yan Lianglong Chen Lianglong Chen Lianglong Chen Qin Chen Qin Chen Qin Chen Yukun Luo Yukun Luo Yukun Luo |
| author_sort | Lihua Chen |
| collection | DOAJ |
| description | IntroductionTo investigate the prognostic value of the consistency between the residual quantitative flow ratio (QFR) and postpercutaneous coronary intervention (PCI) QFR in patients undergoing revascularization.MethodsThis was a single-center, retrospective, observational study. All enrolled patients were divided into five groups according to the ΔQFR (defined as the value of the post-PCI QFR minus the residual QFR): (1) Overanticipated group; (2) Slightly overanticipated group; (3) Consistent group; (4) Slightly underanticipated group; and (5) Underanticipated group. The primary outcome was the 5-year target vessel failure (TVF).ResultsA total of 1373 patients were included in the final analysis. The pre-PCI QFR and post-PCI QFR were significantly different among the five groups. TVF within 5 years occurred in 189 patients in all the groups. The incidence of TVF was significantly greater in the underanticipated group than in the consistent group (P = 0.008), whereas no significant differences were found when comparing the underanticipated group with the other three groups. Restricted cubic spline regression analysis showed that the risk of TVF was nonlinearly related to the ΔQFR. A multivariate Cox regression model revealed that a ΔQFR≤ −0.1 was an independent risk factor for TVF.ConclusionsThe consistency between the residual QFR and post-PCI QFR may be associated with the long-term prognosis of patients. Patients whose post-PCI QFR is significantly lower than the residual QFR may be at greater risk of TVF. An aggressive PCI strategy for lesions is anticipated to have less functional benefit and may not result in a better clinical outcome. |
| first_indexed | 2024-04-24T08:03:07Z |
| format | Article |
| id | doaj.art-bf5e9d3a301c405184ac0f5c789726a4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-24T08:03:07Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-bf5e9d3a301c405184ac0f5c789726a42024-04-17T16:09:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-04-011110.3389/fcvm.2024.12972181297218Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patientsLihua Chen0Lihua Chen1Lihua Chen2Lihua Chen3Jiaxin Zhong4Jiaxin Zhong5Jiaxin Zhong6Ruijin Hong7Ruijin Hong8Ruijin Hong9Yuxiang Chen10Yuxiang Chen11Yuxiang Chen12Beilei Li13Beilei Li14Beilei Li15Laicheng Wang16Laicheng Wang17Laicheng Wang18Yuanming Yan19Yuanming Yan20Yuanming Yan21Lianglong Chen22Lianglong Chen23Lianglong Chen24Qin Chen25Qin Chen26Qin Chen27Yukun Luo28Yukun Luo29Yukun Luo30Department of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaChangle District People's Hospital Cardiovascular Department, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaDepartment of Cardiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaFujian Heart Medical Center, Fujian Medical University Union Hospital, Fuzhou, Fujian, ChinaIntroductionTo investigate the prognostic value of the consistency between the residual quantitative flow ratio (QFR) and postpercutaneous coronary intervention (PCI) QFR in patients undergoing revascularization.MethodsThis was a single-center, retrospective, observational study. All enrolled patients were divided into five groups according to the ΔQFR (defined as the value of the post-PCI QFR minus the residual QFR): (1) Overanticipated group; (2) Slightly overanticipated group; (3) Consistent group; (4) Slightly underanticipated group; and (5) Underanticipated group. The primary outcome was the 5-year target vessel failure (TVF).ResultsA total of 1373 patients were included in the final analysis. The pre-PCI QFR and post-PCI QFR were significantly different among the five groups. TVF within 5 years occurred in 189 patients in all the groups. The incidence of TVF was significantly greater in the underanticipated group than in the consistent group (P = 0.008), whereas no significant differences were found when comparing the underanticipated group with the other three groups. Restricted cubic spline regression analysis showed that the risk of TVF was nonlinearly related to the ΔQFR. A multivariate Cox regression model revealed that a ΔQFR≤ −0.1 was an independent risk factor for TVF.ConclusionsThe consistency between the residual QFR and post-PCI QFR may be associated with the long-term prognosis of patients. Patients whose post-PCI QFR is significantly lower than the residual QFR may be at greater risk of TVF. An aggressive PCI strategy for lesions is anticipated to have less functional benefit and may not result in a better clinical outcome.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1297218/fullquantitative flow ratiopercutaneous coronary interventioncoronary artery diseasetarget vessel failureprognostic value |
| spellingShingle | Lihua Chen Lihua Chen Lihua Chen Lihua Chen Jiaxin Zhong Jiaxin Zhong Jiaxin Zhong Ruijin Hong Ruijin Hong Ruijin Hong Yuxiang Chen Yuxiang Chen Yuxiang Chen Beilei Li Beilei Li Beilei Li Laicheng Wang Laicheng Wang Laicheng Wang Yuanming Yan Yuanming Yan Yuanming Yan Lianglong Chen Lianglong Chen Lianglong Chen Qin Chen Qin Chen Qin Chen Yukun Luo Yukun Luo Yukun Luo Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients Frontiers in Cardiovascular Medicine quantitative flow ratio percutaneous coronary intervention coronary artery disease target vessel failure prognostic value |
| title | Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients |
| title_full | Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients |
| title_fullStr | Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients |
| title_full_unstemmed | Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients |
| title_short | Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients |
| title_sort | predictive value of the inconsistency between the residual and post pci qfr for prognosis in pci patients |
| topic | quantitative flow ratio percutaneous coronary intervention coronary artery disease target vessel failure prognostic value |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1297218/full |
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