NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD

NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD

Abstract Background Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms underpinning its pathogenesis however remain elusive. The dysregulated ex...

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Bibliographic Details
Main Authors: Xiaotong Guo, Yuchun Fan, Jieda Cui, Binwei Hao, Li Zhu, Xiao Sun, Jinxi He, Jiali Yang, Jianda Dong, Yanyang Wang, Xiaoming Liu, Juan Chen
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Pulmonary Medicine
Subjects:
Pulmonary hypertension
Chronic obstructive pulmonary disease
Cardiac magnetic resonance imaging
Pulmonary arteriolar remodeling
Nicotinamide adenine dinucleotide phosphate oxidase subunit 4
Online Access:http://link.springer.com/article/10.1186/s12890-018-0680-y

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