Tissue management in precision medicine: What the pathologist needs to know in the molecular era
Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.983102/full |
| _version_ | 1797991853780369408 |
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| author | Ricella Souza da Silva Regina Pinto Luis Cirnes Fernando Schmitt Fernando Schmitt Fernando Schmitt |
| author_facet | Ricella Souza da Silva Regina Pinto Luis Cirnes Fernando Schmitt Fernando Schmitt Fernando Schmitt |
| author_sort | Ricella Souza da Silva |
| collection | DOAJ |
| description | Precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the implementation and development of molecular tests that are in the center of decision of many therapeutic choices. Besides many laboratory procedures directly involved in the molecular tests, is fundamental to guarantee that tissues and cells collected for analysis be managed correctly before the DNA/RNA extraction. In this paper we explore the pivotal and interconnected points that can influence molecular studies, such as pre-analytical issues (fixation and decalcification); diagnosis and material selection, including the calculation of nuclei neoplastic fraction. The standardization of sample processing and morphological control ensures the accuracy of the diagnosis. Tissue or cytological samples constitutes the main foundation for the determination of biomarkers and development of druggable targets. Pathology and precision oncology still have a long way to go in terms of research and clinical practice: improving the accuracy and dissemination of molecular tests, learning in molecular tumor boards for advanced disease, and knowledge about early disease. Precision medicine needs pathology to be precise. |
| first_indexed | 2024-04-11T08:58:45Z |
| format | Article |
| id | doaj.art-bf606db208d049c7bbabfc8602f03c61 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T08:58:45Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-bf606db208d049c7bbabfc8602f03c612022-12-22T04:33:05ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-10-01910.3389/fmolb.2022.983102983102Tissue management in precision medicine: What the pathologist needs to know in the molecular eraRicella Souza da Silva0Regina Pinto1Luis Cirnes2Fernando Schmitt3Fernando Schmitt4Fernando Schmitt5IPATIMUP Diagnostics, IPATIMUP—Institute of Molecular Pathology and Immunology of Porto University, University of Porto, Porto, PortugalIPATIMUP Diagnostics, IPATIMUP—Institute of Molecular Pathology and Immunology of Porto University, University of Porto, Porto, PortugalIPATIMUP Diagnostics, IPATIMUP—Institute of Molecular Pathology and Immunology of Porto University, University of Porto, Porto, PortugalIPATIMUP Diagnostics, IPATIMUP—Institute of Molecular Pathology and Immunology of Porto University, University of Porto, Porto, PortugalDepartment of Pathology, Faculty of Medicine of the University of Porto, University of Porto, Porto, PortugalCINTESIS@RISE (Health Research Network), Porto, PortugalPrecision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” Among many medical specialists involved in precision medicine, the pathologists play an important and key role in the implementation and development of molecular tests that are in the center of decision of many therapeutic choices. Besides many laboratory procedures directly involved in the molecular tests, is fundamental to guarantee that tissues and cells collected for analysis be managed correctly before the DNA/RNA extraction. In this paper we explore the pivotal and interconnected points that can influence molecular studies, such as pre-analytical issues (fixation and decalcification); diagnosis and material selection, including the calculation of nuclei neoplastic fraction. The standardization of sample processing and morphological control ensures the accuracy of the diagnosis. Tissue or cytological samples constitutes the main foundation for the determination of biomarkers and development of druggable targets. Pathology and precision oncology still have a long way to go in terms of research and clinical practice: improving the accuracy and dissemination of molecular tests, learning in molecular tumor boards for advanced disease, and knowledge about early disease. Precision medicine needs pathology to be precise.https://www.frontiersin.org/articles/10.3389/fmolb.2022.983102/fullmolecular pathologymorphological controloncology precisionpersonalized medicinetissue managementsolid tumors |
| spellingShingle | Ricella Souza da Silva Regina Pinto Luis Cirnes Fernando Schmitt Fernando Schmitt Fernando Schmitt Tissue management in precision medicine: What the pathologist needs to know in the molecular era Frontiers in Molecular Biosciences molecular pathology morphological control oncology precision personalized medicine tissue management solid tumors |
| title | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
| title_full | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
| title_fullStr | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
| title_full_unstemmed | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
| title_short | Tissue management in precision medicine: What the pathologist needs to know in the molecular era |
| title_sort | tissue management in precision medicine what the pathologist needs to know in the molecular era |
| topic | molecular pathology morphological control oncology precision personalized medicine tissue management solid tumors |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.983102/full |
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