Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota
Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating...
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MDPI AG
2021-08-01
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| author | Ryuta Ejima Masahiro Akiyama Hiroki Sato Sawako Tomioka Kyosuke Yakabe Tatsuki Kimizuka Natsumi Seki Yumiko Fujimura Akiyoshi Hirayama Shinji Fukuda Koji Hase Yun-Gi Kim |
| author_facet | Ryuta Ejima Masahiro Akiyama Hiroki Sato Sawako Tomioka Kyosuke Yakabe Tatsuki Kimizuka Natsumi Seki Yumiko Fujimura Akiyoshi Hirayama Shinji Fukuda Koji Hase Yun-Gi Kim |
| author_sort | Ryuta Ejima |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of <i>Bacteroides</i>. Antibiotic treatment completely abolished the suppressive effects of SA on MetS. Mechanistically, SA decreased the number of colonic inflammatory monocytes, which promote MetS development, in a gut microbiota-dependent manner. The abundance of <i>Bacteroides</i> was negatively correlated with that of inflammatory monocytes and positively correlated with the levels of several gut metabolites. The present study revealed a novel food function of SA in preventing HFD-induced MetS through its action on gut microbiota. |
| first_indexed | 2024-03-10T08:30:32Z |
| format | Article |
| id | doaj.art-bf613ed1fd454095ade0acc4f0e40de2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:30:32Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-bf613ed1fd454095ade0acc4f0e40de22023-11-22T09:06:30ZengMDPI AGNutrients2072-66432021-08-01138281210.3390/nu13082812Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut MicrobiotaRyuta Ejima0Masahiro Akiyama1Hiroki Sato2Sawako Tomioka3Kyosuke Yakabe4Tatsuki Kimizuka5Natsumi Seki6Yumiko Fujimura7Akiyoshi Hirayama8Shinji Fukuda9Koji Hase10Yun-Gi Kim11Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanInstitute for Advanced Biosciences, Keio University, Yamagata 997-0052, JapanInstitute for Advanced Biosciences, Keio University, Yamagata 997-0052, JapanDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanMetabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of <i>Bacteroides</i>. Antibiotic treatment completely abolished the suppressive effects of SA on MetS. Mechanistically, SA decreased the number of colonic inflammatory monocytes, which promote MetS development, in a gut microbiota-dependent manner. The abundance of <i>Bacteroides</i> was negatively correlated with that of inflammatory monocytes and positively correlated with the levels of several gut metabolites. The present study revealed a novel food function of SA in preventing HFD-induced MetS through its action on gut microbiota.https://www.mdpi.com/2072-6643/13/8/2812gut microbiotametabolic syndromeinflammatory monocytes |
| spellingShingle | Ryuta Ejima Masahiro Akiyama Hiroki Sato Sawako Tomioka Kyosuke Yakabe Tatsuki Kimizuka Natsumi Seki Yumiko Fujimura Akiyoshi Hirayama Shinji Fukuda Koji Hase Yun-Gi Kim Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota Nutrients gut microbiota metabolic syndrome inflammatory monocytes |
| title | Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota |
| title_full | Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota |
| title_fullStr | Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota |
| title_full_unstemmed | Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota |
| title_short | Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota |
| title_sort | seaweed dietary fiber sodium alginate suppresses the migration of colonic inflammatory monocytes and diet induced metabolic syndrome via the gut microbiota |
| topic | gut microbiota metabolic syndrome inflammatory monocytes |
| url | https://www.mdpi.com/2072-6643/13/8/2812 |
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