The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients
Objective To assess the impact of Modic changes (MC) on preoperative symptoms, and postoperative outcomes in anterior cervical discectomy and fusion (ACDF) patients. Methods We performed a retrospective study of prospectively collected data of ACDF patients at a single institution. Preoperative magn...
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| Format: | Article |
| Language: | English |
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Korean Spinal Neurosurgery Society
2020-03-01
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| Series: | Neurospine |
| Subjects: | |
| Online Access: | http://www.e-neurospine.org/upload/pdf/ns-2040062-031.pdf |
| _version_ | 1827362717524033536 |
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| author | James D. Baker Garrett K. Harada Youping Tao Philip K. Louie Bryce A. Basques Fabio Galbusera Frank Niemeyer Hans-Joachim Wilke Howard S. An Dino Samartzis |
| author_facet | James D. Baker Garrett K. Harada Youping Tao Philip K. Louie Bryce A. Basques Fabio Galbusera Frank Niemeyer Hans-Joachim Wilke Howard S. An Dino Samartzis |
| author_sort | James D. Baker |
| collection | DOAJ |
| description | Objective To assess the impact of Modic changes (MC) on preoperative symptoms, and postoperative outcomes in anterior cervical discectomy and fusion (ACDF) patients. Methods We performed a retrospective study of prospectively collected data of ACDF patients at a single institution. Preoperative magnetic resonance imagings were used to assess the presence of MC. MC were stratified by type and location, and compared to patients without MC. Associations with symptoms, patient-reported measures, and surgical outcomes were assessed. Results A total of 861 patients were included, with 356 patients with MC (41.3%). MC more frequently occurred at C5–6 (15.1%), and type II was the most common type (61.2%). MC were associated with advanced age (p < 0.001), more levels fused (p < 0.001), a longer duration of symptoms, but not with specific symptoms. MC at C7–T1 resulted in higher postoperative disability (p < 0.001), but did not increase risk of adjacent segment degeneration or reoperation. Conclusion This study is the first to systematically examine the impact of cervical MC, stratified by type and location, on outcomes in ACDF patients. Patients with MC were generally older, required larger fusions, and had longer duration of preoperative symptoms. While MC may not affect specific outcomes following ACDF, they may indicate a more debilitating preoperative state for patients. |
| first_indexed | 2024-03-08T07:33:27Z |
| format | Article |
| id | doaj.art-bf6159dc348f491f80ad1c2ec2a38b39 |
| institution | Directory Open Access Journal |
| issn | 2586-6583 2586-6591 |
| language | English |
| last_indexed | 2024-03-08T07:33:27Z |
| publishDate | 2020-03-01 |
| publisher | Korean Spinal Neurosurgery Society |
| record_format | Article |
| series | Neurospine |
| spelling | doaj.art-bf6159dc348f491f80ad1c2ec2a38b392024-02-02T19:53:10ZengKorean Spinal Neurosurgery SocietyNeurospine2586-65832586-65912020-03-0117119020310.14245/ns.2040062.031970The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion PatientsJames D. Baker0Garrett K. Harada1Youping Tao2Philip K. Louie3Bryce A. Basques4Fabio Galbusera5Frank Niemeyer6Hans-Joachim Wilke7Howard S. An8Dino Samartzis9 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA IRCCS Istituto Ortopedico Galeazzi, Milan, Italy Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Ulm, Germany Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USAObjective To assess the impact of Modic changes (MC) on preoperative symptoms, and postoperative outcomes in anterior cervical discectomy and fusion (ACDF) patients. Methods We performed a retrospective study of prospectively collected data of ACDF patients at a single institution. Preoperative magnetic resonance imagings were used to assess the presence of MC. MC were stratified by type and location, and compared to patients without MC. Associations with symptoms, patient-reported measures, and surgical outcomes were assessed. Results A total of 861 patients were included, with 356 patients with MC (41.3%). MC more frequently occurred at C5–6 (15.1%), and type II was the most common type (61.2%). MC were associated with advanced age (p < 0.001), more levels fused (p < 0.001), a longer duration of symptoms, but not with specific symptoms. MC at C7–T1 resulted in higher postoperative disability (p < 0.001), but did not increase risk of adjacent segment degeneration or reoperation. Conclusion This study is the first to systematically examine the impact of cervical MC, stratified by type and location, on outcomes in ACDF patients. Patients with MC were generally older, required larger fusions, and had longer duration of preoperative symptoms. While MC may not affect specific outcomes following ACDF, they may indicate a more debilitating preoperative state for patients.http://www.e-neurospine.org/upload/pdf/ns-2040062-031.pdfspinediskectomymagnetic resonance imagingintervertebral disc degenerationpatient outcome assessment |
| spellingShingle | James D. Baker Garrett K. Harada Youping Tao Philip K. Louie Bryce A. Basques Fabio Galbusera Frank Niemeyer Hans-Joachim Wilke Howard S. An Dino Samartzis The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients Neurospine spine diskectomy magnetic resonance imaging intervertebral disc degeneration patient outcome assessment |
| title | The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients |
| title_full | The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients |
| title_fullStr | The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients |
| title_full_unstemmed | The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients |
| title_short | The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients |
| title_sort | impact of modic changes on preoperative symptoms and clinical outcomes in anterior cervical discectomy and fusion patients |
| topic | spine diskectomy magnetic resonance imaging intervertebral disc degeneration patient outcome assessment |
| url | http://www.e-neurospine.org/upload/pdf/ns-2040062-031.pdf |
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