Kinome inhibition states and multiomics data enable prediction of cell viability in diverse cancer types.
Protein kinases play a vital role in a wide range of cellular processes, and compounds that inhibit kinase activity emerging as a primary focus for targeted therapy development, especially in cancer. Consequently, efforts to characterize the behavior of kinases in response to inhibitor treatment, as...
Main Authors: | Matthew E Berginski, Chinmaya U Joisa, Brian T Golitz, Shawn M Gomez |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-02-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1010888 |
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