Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome
Abstract Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID‐19 impairs the O2/CO2 exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r‐tPA) has been nebulized to 3 critically ill COVID‐19 patients in order to resolve the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.6283 |
| _version_ | 1811208283467284480 |
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| author | Shahideh Amini Zohre Labbani‐Motlagh Rasoul Aliannejad Seyed Mohammad Pourabbas Mohammad Vasei |
| author_facet | Shahideh Amini Zohre Labbani‐Motlagh Rasoul Aliannejad Seyed Mohammad Pourabbas Mohammad Vasei |
| author_sort | Shahideh Amini |
| collection | DOAJ |
| description | Abstract Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID‐19 impairs the O2/CO2 exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r‐tPA) has been nebulized to 3 critically ill COVID‐19 patients in order to resolve the deposited fibrin while avoiding the risk of bleeding. Based on these observations, nebulization of r‐tPA may be a potential therapeutic approach and new area of research for future studies. |
| first_indexed | 2024-04-12T04:19:14Z |
| format | Article |
| id | doaj.art-bf65d8d2fa274850a843472cd4acba09 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-12T04:19:14Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-bf65d8d2fa274850a843472cd4acba092022-12-22T03:48:17ZengWileyClinical Case Reports2050-09042022-09-01109n/an/a10.1002/ccr3.6283Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndromeShahideh Amini0Zohre Labbani‐Motlagh1Rasoul Aliannejad2Seyed Mohammad Pourabbas3Mohammad Vasei4Department of Clinical Pharmacy, Faculty of Pharmacy Tehran University of Medical Science Tehran IranDepartment of Clinical Pharmacy Tehran University of Medical Science Tehran IranDepartment of Clinical Pharmacy, Faculty of Pharmacy Tehran University of Medical Science Tehran IranDepartment of Internal Medicine, Shari'ati Hospital Tehran University of Medical Science Tehran IranCell‐Based Therapies Research Center, Digestive Disease Research Institute, Shari'ati Hospital Tehran University of Medical Science Tehran IranAbstract Fibrin deposition in the alveolar spaces during pulmonary involvement of COVID‐19 impairs the O2/CO2 exchange and leads to respiratory symptoms. In this report, Recombinant Tissue Plasminogen Activator (r‐tPA) has been nebulized to 3 critically ill COVID‐19 patients in order to resolve the deposited fibrin while avoiding the risk of bleeding. Based on these observations, nebulization of r‐tPA may be a potential therapeutic approach and new area of research for future studies.https://doi.org/10.1002/ccr3.6283ARDSCOVID‐19fibrinolysisrecombinant tissue plasminogen activatorr‐tPA |
| spellingShingle | Shahideh Amini Zohre Labbani‐Motlagh Rasoul Aliannejad Seyed Mohammad Pourabbas Mohammad Vasei Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome Clinical Case Reports ARDS COVID‐19 fibrinolysis recombinant tissue plasminogen activator r‐tPA |
| title | Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome |
| title_full | Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome |
| title_fullStr | Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome |
| title_full_unstemmed | Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome |
| title_short | Case series of nebulizing r‐tPA for COVID‐19 induced acute respiratory distress syndrome |
| title_sort | case series of nebulizing r tpa for covid 19 induced acute respiratory distress syndrome |
| topic | ARDS COVID‐19 fibrinolysis recombinant tissue plasminogen activator r‐tPA |
| url | https://doi.org/10.1002/ccr3.6283 |
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