Immediate effects of tDCS on the µ-opioid system of a chronic pain patient
We developed a unique protocol where transcranial direct current stimulation (tDCS) of the motor cortex is performed during positron emission tomography (PET) scan using a µ-opioid receptor (µOR) selective radiotracer, [11C]carfentanil. This is one of the most important central neu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-11-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00093/full |
| _version_ | 1819265009142726656 |
|---|---|
| author | Marcos Fabio DosSantos Marcos Fabio DosSantos Tiffany M Love Ilkka Kristian Martikainen Ilkka Kristian Martikainen Thiago Dias Nascimento Felipe eFregni Chelsea eCummiford Misty Dawn Deboer Jon Kar Zubieta Alexandre F DaSilva |
| author_facet | Marcos Fabio DosSantos Marcos Fabio DosSantos Tiffany M Love Ilkka Kristian Martikainen Ilkka Kristian Martikainen Thiago Dias Nascimento Felipe eFregni Chelsea eCummiford Misty Dawn Deboer Jon Kar Zubieta Alexandre F DaSilva |
| author_sort | Marcos Fabio DosSantos |
| collection | DOAJ |
| description | We developed a unique protocol where transcranial direct current stimulation (tDCS) of the motor cortex is performed during positron emission tomography (PET) scan using a µ-opioid receptor (µOR) selective radiotracer, [11C]carfentanil. This is one of the most important central neuromechanisms associated with pain perception and regulation. We measured µOR non-displaceable binding potential (µOR BPND) in a trigeminal neuropathic pain patient (TNP) without creating artifacts, or posing risks to the patient (e.g., monitoring of resistance). The active session directly improved in 36.2% the threshold for experimental cold pain in the trigeminal allodynic area, mandibular branch, but not the TNP patient’s clinical pain. Interestingly, the single active tDCS application considerably decreased µORBPND levels in (sub)cortical pain-matrix structures compared to sham tDCS, especially in the posterior thalamus. Suggesting that the µ-opioidergic effects of a single tDCS session are subclinical at immediate level, and repetitive sessions are necessary to revert ingrained neuroplastic changes related to the chronic pain. To our knowledge, we provide data for the first time in-vivo that there is possibly an instant increase of endogenous µ-opioid release during acute motor cortex neuromodulation with tDCS. |
| first_indexed | 2024-12-23T20:38:33Z |
| format | Article |
| id | doaj.art-bf6616278b8541c397170a9e5d93eff6 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-23T20:38:33Z |
| publishDate | 2012-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-bf6616278b8541c397170a9e5d93eff62022-12-21T17:32:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402012-11-01310.3389/fpsyt.2012.0009331714Immediate effects of tDCS on the µ-opioid system of a chronic pain patientMarcos Fabio DosSantos0Marcos Fabio DosSantos1Tiffany M Love2Ilkka Kristian Martikainen3Ilkka Kristian Martikainen4Thiago Dias Nascimento5Felipe eFregni6Chelsea eCummiford7Misty Dawn Deboer8Jon Kar Zubieta9Alexandre F DaSilva10University of MichiganUniversidade Federal do Rio de JaneiroUniversity of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganHarvard UniversityUniversity of MichiganUniversity of MichiganUniversity of MichiganUniversity of MichiganWe developed a unique protocol where transcranial direct current stimulation (tDCS) of the motor cortex is performed during positron emission tomography (PET) scan using a µ-opioid receptor (µOR) selective radiotracer, [11C]carfentanil. This is one of the most important central neuromechanisms associated with pain perception and regulation. We measured µOR non-displaceable binding potential (µOR BPND) in a trigeminal neuropathic pain patient (TNP) without creating artifacts, or posing risks to the patient (e.g., monitoring of resistance). The active session directly improved in 36.2% the threshold for experimental cold pain in the trigeminal allodynic area, mandibular branch, but not the TNP patient’s clinical pain. Interestingly, the single active tDCS application considerably decreased µORBPND levels in (sub)cortical pain-matrix structures compared to sham tDCS, especially in the posterior thalamus. Suggesting that the µ-opioidergic effects of a single tDCS session are subclinical at immediate level, and repetitive sessions are necessary to revert ingrained neuroplastic changes related to the chronic pain. To our knowledge, we provide data for the first time in-vivo that there is possibly an instant increase of endogenous µ-opioid release during acute motor cortex neuromodulation with tDCS.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00093/fullneuroplasticityPETtDCSopioid receptorsTrigeminal Neuropathic PainPost-herpetic Neuralgia |
| spellingShingle | Marcos Fabio DosSantos Marcos Fabio DosSantos Tiffany M Love Ilkka Kristian Martikainen Ilkka Kristian Martikainen Thiago Dias Nascimento Felipe eFregni Chelsea eCummiford Misty Dawn Deboer Jon Kar Zubieta Alexandre F DaSilva Immediate effects of tDCS on the µ-opioid system of a chronic pain patient Frontiers in Psychiatry neuroplasticity PET tDCS opioid receptors Trigeminal Neuropathic Pain Post-herpetic Neuralgia |
| title | Immediate effects of tDCS on the µ-opioid system of a chronic pain patient |
| title_full | Immediate effects of tDCS on the µ-opioid system of a chronic pain patient |
| title_fullStr | Immediate effects of tDCS on the µ-opioid system of a chronic pain patient |
| title_full_unstemmed | Immediate effects of tDCS on the µ-opioid system of a chronic pain patient |
| title_short | Immediate effects of tDCS on the µ-opioid system of a chronic pain patient |
| title_sort | immediate effects of tdcs on the 181 opioid system of a chronic pain patient |
| topic | neuroplasticity PET tDCS opioid receptors Trigeminal Neuropathic Pain Post-herpetic Neuralgia |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2012.00093/full |
| work_keys_str_mv | AT marcosfabiodossantos immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT marcosfabiodossantos immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT tiffanymlove immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT ilkkakristianmartikainen immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT ilkkakristianmartikainen immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT thiagodiasnascimento immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT felipeefregni immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT chelseaecummiford immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT mistydawndeboer immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT jonkarzubieta immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient AT alexandrefdasilva immediateeffectsoftdcsonthe181opioidsystemofachronicpainpatient |