In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein

In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein

α-Synuclein aggregation is a common trait in synucleinopathies, including Parkinson's disease. Being an unstructured protein, α-synuclein exists in several distinct conformational intermediates, contributing to both its function and pathogenesis. However, the regulation of these monomer conform...

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Bibliographic Details
Main Authors:	Wenmao Huang, Jingzhun Liu, Shimin Le, Mingxi Yao, Yi Shi, Jie Yan
Format:	Article
Language:	English
Published:	AIP Publishing LLC 2024-03-01
Series:	APL Bioengineering
Online Access:	http://dx.doi.org/10.1063/5.0188714

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