Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia.
In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0161539 |
| _version_ | 1819145803730518016 |
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| author | Holly Edwards Mara Rubenstein Alan A Dombkowski J Timothy Caldwell Roland Chu Ana C Xavier Ryan Thummel Melody Neely Larry H Matherly Yubin Ge Jeffrey W Taub |
| author_facet | Holly Edwards Mara Rubenstein Alan A Dombkowski J Timothy Caldwell Roland Chu Ana C Xavier Ryan Thummel Melody Neely Larry H Matherly Yubin Ge Jeffrey W Taub |
| author_sort | Holly Edwards |
| collection | DOAJ |
| description | In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the presenting WBC count (< 50,000/cumm vs > 50,000). We further confirmed that IL1R1, BCAR3, KCNH2, PIR, and ZDHHC23 were differentially expressed in a larger cohort of ETV6-RUNX1-negative BP-ALL patient samples. Statistical analysis demonstrated that expression levels of these genes could accurately categorize high and low WBC count subjects using two independent patient sets, representing positive and negative ETV6-RUNX1 cases. Further studies in leukemia cell line models will better delineate the role of these genes in regulating the white blood cell count and potentially identify new therapeutic targets. |
| first_indexed | 2024-12-22T13:03:50Z |
| format | Article |
| id | doaj.art-bf68ff7fa70f4596baf19a578a6a8903 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T13:03:50Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bf68ff7fa70f4596baf19a578a6a89032022-12-21T18:24:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e016153910.1371/journal.pone.0161539Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia.Holly EdwardsMara RubensteinAlan A DombkowskiJ Timothy CaldwellRoland ChuAna C XavierRyan ThummelMelody NeelyLarry H MatherlyYubin GeJeffrey W TaubIn this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identified 16 differentially expressed genes based on the presenting WBC count (< 50,000/cumm vs > 50,000). We further confirmed that IL1R1, BCAR3, KCNH2, PIR, and ZDHHC23 were differentially expressed in a larger cohort of ETV6-RUNX1-negative BP-ALL patient samples. Statistical analysis demonstrated that expression levels of these genes could accurately categorize high and low WBC count subjects using two independent patient sets, representing positive and negative ETV6-RUNX1 cases. Further studies in leukemia cell line models will better delineate the role of these genes in regulating the white blood cell count and potentially identify new therapeutic targets.https://doi.org/10.1371/journal.pone.0161539 |
| spellingShingle | Holly Edwards Mara Rubenstein Alan A Dombkowski J Timothy Caldwell Roland Chu Ana C Xavier Ryan Thummel Melody Neely Larry H Matherly Yubin Ge Jeffrey W Taub Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. PLoS ONE |
| title | Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. |
| title_full | Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. |
| title_fullStr | Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. |
| title_full_unstemmed | Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. |
| title_short | Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. |
| title_sort | gene signature of high white blood cell count in b precursor acute lymphoblastic leukemia |
| url | https://doi.org/10.1371/journal.pone.0161539 |
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