Immunogenetic clustering of 30 cancers
Abstract Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared heritability of different types of cancer. In this immunogenetic epidemiological study we first computed a Cancer-HLA profile for 30 cancer types characterized by the correlation between the prevalence of eac...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11366-7 |
| _version_ | 1811304871219953664 |
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| author | Lisa M. James Apostolos P. Georgopoulos |
| author_facet | Lisa M. James Apostolos P. Georgopoulos |
| author_sort | Lisa M. James |
| collection | DOAJ |
| description | Abstract Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared heritability of different types of cancer. In this immunogenetic epidemiological study we first computed a Cancer-HLA profile for 30 cancer types characterized by the correlation between the prevalence of each cancer and the population frequency of 127 HLA alleles, and then used multidimensional scaling to evaluate the possible clustering of those Cancer-HLA associations. The results indicated the presence of three clusters, broadly reflecting digestive-skin-cervical cancers, reproductive and endocrine systems cancers, and brain and androgen-associated cancers. The clustering of cancer types documented here is discussed in terms of mechanisms underlying shared Cancer-HLA associations. |
| first_indexed | 2024-04-13T08:15:06Z |
| format | Article |
| id | doaj.art-bf69905d537e47088b853062bd05f00b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T08:15:06Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bf69905d537e47088b853062bd05f00b2022-12-22T02:54:50ZengNature PortfolioScientific Reports2045-23222022-05-0112111410.1038/s41598-022-11366-7Immunogenetic clustering of 30 cancersLisa M. James0Apostolos P. Georgopoulos1The HLA Research Group, Brain Sciences Center (11B), Department of Veterans Affairs Health Care System, Minneapolis VAHCSThe HLA Research Group, Brain Sciences Center (11B), Department of Veterans Affairs Health Care System, Minneapolis VAHCSAbstract Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared heritability of different types of cancer. In this immunogenetic epidemiological study we first computed a Cancer-HLA profile for 30 cancer types characterized by the correlation between the prevalence of each cancer and the population frequency of 127 HLA alleles, and then used multidimensional scaling to evaluate the possible clustering of those Cancer-HLA associations. The results indicated the presence of three clusters, broadly reflecting digestive-skin-cervical cancers, reproductive and endocrine systems cancers, and brain and androgen-associated cancers. The clustering of cancer types documented here is discussed in terms of mechanisms underlying shared Cancer-HLA associations.https://doi.org/10.1038/s41598-022-11366-7 |
| spellingShingle | Lisa M. James Apostolos P. Georgopoulos Immunogenetic clustering of 30 cancers Scientific Reports |
| title | Immunogenetic clustering of 30 cancers |
| title_full | Immunogenetic clustering of 30 cancers |
| title_fullStr | Immunogenetic clustering of 30 cancers |
| title_full_unstemmed | Immunogenetic clustering of 30 cancers |
| title_short | Immunogenetic clustering of 30 cancers |
| title_sort | immunogenetic clustering of 30 cancers |
| url | https://doi.org/10.1038/s41598-022-11366-7 |
| work_keys_str_mv | AT lisamjames immunogeneticclusteringof30cancers AT apostolospgeorgopoulos immunogeneticclusteringof30cancers |