Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content
Backgroud and aim: Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem, which associated with systemic health problems and causes a higher risk of all-cause mortality. The leading causes of death in NAFLD patients are cardiac complications followed by NAFLD-related liver complica...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-06-01
|
| Series: | Liver Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S254256842200023X |
| _version_ | 1818546603718344704 |
|---|---|
| author | Xi Chen Hui-Quan Wen Qing-Ling Li Li-Shan Shen Xiao-Wen Luo Bin Zhou Ruo-Mi Guo |
| author_facet | Xi Chen Hui-Quan Wen Qing-Ling Li Li-Shan Shen Xiao-Wen Luo Bin Zhou Ruo-Mi Guo |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | Backgroud and aim: Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem, which associated with systemic health problems and causes a higher risk of all-cause mortality. The leading causes of death in NAFLD patients are cardiac complications followed by NAFLD-related liver complications. This study aimed to quantitatively measure the contents of liver and cardiac fat with varying degrees of NAFLD in an obese group and a type 2 diabetes mellitus (T2DM) group to explore differences and correlations. Materials and methods: This study included 170 patients who underwent echo asymmetry and least square estimation-iron quantification sequencing at 3.0 T magnetic resonance imaging. Fat fraction values were quantitatively measured in regions of interest of the liver, myocardium, and periapical adipose tissue. Results: In both the obese and T2DM groups, cardiac fat content was correlated with liver fat content using linear regression (P < 0.01). For both the obese and T2DM groups, myocardial fat was higher in the T2DM group than that in the obese group (ventricular septum, 3.33% ± 1.40% vs. 2.51% ± 0.88%; the left ventricle, 3.38% ± 1.43% vs. 2.26% ± 0.87%). For the T2DM group, the different myocardial fat contents and myocardial enzymes were positively correlated with fatty liver severity by multiple comparisons of different degrees of NAFLD (P < 0.05). Periapical fat was statistically significant only between mild fatty and normal liver (obese group, P < 0.01; T2DM group, P = 0.01). Conclusion: T2DM patients with fatty liver had higher myocardial fat content than obese patients with fatty liver, and both had a linear relationship. Periapical fat is an index for liver fat deposition in patients. The myocardial fat contents in T2DM patients with an increase in the liver fat content, which would influence cardiac function, should be given more attention in clinic. |
| first_indexed | 2024-12-12T07:55:26Z |
| format | Article |
| id | doaj.art-bf6ec69f79dc43ba8ff3d3187046fa25 |
| institution | Directory Open Access Journal |
| issn | 2542-5684 |
| language | English |
| last_indexed | 2024-12-12T07:55:26Z |
| publishDate | 2022-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj.art-bf6ec69f79dc43ba8ff3d3187046fa252022-12-22T00:32:20ZengKeAi Communications Co., Ltd.Liver Research2542-56842022-06-0162103110Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat contentXi Chen0Hui-Quan Wen1Qing-Ling Li2Li-Shan Shen3Xiao-Wen Luo4Bin Zhou5Ruo-Mi Guo6Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of VIP Medical Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Corresponding author. Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Corresponding author. Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Backgroud and aim: Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem, which associated with systemic health problems and causes a higher risk of all-cause mortality. The leading causes of death in NAFLD patients are cardiac complications followed by NAFLD-related liver complications. This study aimed to quantitatively measure the contents of liver and cardiac fat with varying degrees of NAFLD in an obese group and a type 2 diabetes mellitus (T2DM) group to explore differences and correlations. Materials and methods: This study included 170 patients who underwent echo asymmetry and least square estimation-iron quantification sequencing at 3.0 T magnetic resonance imaging. Fat fraction values were quantitatively measured in regions of interest of the liver, myocardium, and periapical adipose tissue. Results: In both the obese and T2DM groups, cardiac fat content was correlated with liver fat content using linear regression (P < 0.01). For both the obese and T2DM groups, myocardial fat was higher in the T2DM group than that in the obese group (ventricular septum, 3.33% ± 1.40% vs. 2.51% ± 0.88%; the left ventricle, 3.38% ± 1.43% vs. 2.26% ± 0.87%). For the T2DM group, the different myocardial fat contents and myocardial enzymes were positively correlated with fatty liver severity by multiple comparisons of different degrees of NAFLD (P < 0.05). Periapical fat was statistically significant only between mild fatty and normal liver (obese group, P < 0.01; T2DM group, P = 0.01). Conclusion: T2DM patients with fatty liver had higher myocardial fat content than obese patients with fatty liver, and both had a linear relationship. Periapical fat is an index for liver fat deposition in patients. The myocardial fat contents in T2DM patients with an increase in the liver fat content, which would influence cardiac function, should be given more attention in clinic.http://www.sciencedirect.com/science/article/pii/S254256842200023XCardiac fat contentDiabetes mellitusObesityNon-alcoholic fatty liver disease (NAFLD)Type 2 diabetes mellitus (T2DM)Magnetic resonance imaging (MRI) |
| spellingShingle | Xi Chen Hui-Quan Wen Qing-Ling Li Li-Shan Shen Xiao-Wen Luo Bin Zhou Ruo-Mi Guo Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content Liver Research Cardiac fat content Diabetes mellitus Obesity Non-alcoholic fatty liver disease (NAFLD) Type 2 diabetes mellitus (T2DM) Magnetic resonance imaging (MRI) |
| title | Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content |
| title_full | Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content |
| title_fullStr | Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content |
| title_full_unstemmed | Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content |
| title_short | Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content |
| title_sort | quantification of liver fat deposition in obese and diabetic patients a pilot study on the correlation with myocardium and periapical fat content |
| topic | Cardiac fat content Diabetes mellitus Obesity Non-alcoholic fatty liver disease (NAFLD) Type 2 diabetes mellitus (T2DM) Magnetic resonance imaging (MRI) |
| url | http://www.sciencedirect.com/science/article/pii/S254256842200023X |
| work_keys_str_mv | AT xichen quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT huiquanwen quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT qinglingli quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT lishanshen quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT xiaowenluo quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT binzhou quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent AT ruomiguo quantificationofliverfatdepositioninobeseanddiabeticpatientsapilotstudyonthecorrelationwithmyocardiumandperiapicalfatcontent |