The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats
Aluminum recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine the effectiveness of curcumin (CUR) in reducing the toxicity of aluminum chloride (AlCl3). In this experimental study, forty male Wista...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-03-01
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| Series: | Pharmaceutical and Biomedical Research |
| Subjects: | |
| Online Access: | http://pbr.mazums.ac.ir/article-1-222-en.html |
| _version_ | 1819172141344489472 |
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| author | Ebrahim Cheraghi Kambiz Roshanaei |
| author_facet | Ebrahim Cheraghi Kambiz Roshanaei |
| author_sort | Ebrahim Cheraghi |
| collection | DOAJ |
| description | Aluminum recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine the effectiveness of curcumin (CUR) in reducing the toxicity of aluminum chloride (AlCl3). In this experimental study, forty male Wistar rats were allocated to five groups (N = 8), viz. no treatment (control), solvent (DMSO or distilled water), CUR (10 mg/kg B.W.), AlCl3 (10 mg/kg B.W.), and CUR+AlCl3 (each with 10 mg/kg B.W.). Treatments were performed by intra-peritoneal injections for 28 days. On the final day, animals were sacrificed, and liver function markers in blood plasma, hepatic antioxidants, and lipid peroxidation index in liver homogenate were estimated. AlCl3 treatment resulted in a significant increase in plasma AST, ALT, ALP and LDH activities with decreased total protein compared to control. AlCl3 significantly reduced superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels but increased malondialdehyde (MDA) level in the liver compared to control. AlCl3 also caused various histopathological changes in the livers of rats. Curcumin could normalize nearly all these parameters. CUR improved levels of changes in different parameters when was combined with AlCl3. It is concluded that CUR has beneficial influences being able to antagonize AlCl3 toxicity. |
| first_indexed | 2024-12-22T20:02:28Z |
| format | Article |
| id | doaj.art-bf702ac633884a5d8b555b70372d3cbc |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-22T20:02:28Z |
| publishDate | 2019-03-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-bf702ac633884a5d8b555b70372d3cbc2022-12-21T18:14:15ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942019-03-01511118The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male ratsEbrahim Cheraghi0Kambiz Roshanaei1 Department of Biology, Faculty of Sciences, University of Qom, Qom, Iran Department of Biology, Faculty of Sciences, Qom Branch, Islamic Azad University, Qom Aluminum recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine the effectiveness of curcumin (CUR) in reducing the toxicity of aluminum chloride (AlCl3). In this experimental study, forty male Wistar rats were allocated to five groups (N = 8), viz. no treatment (control), solvent (DMSO or distilled water), CUR (10 mg/kg B.W.), AlCl3 (10 mg/kg B.W.), and CUR+AlCl3 (each with 10 mg/kg B.W.). Treatments were performed by intra-peritoneal injections for 28 days. On the final day, animals were sacrificed, and liver function markers in blood plasma, hepatic antioxidants, and lipid peroxidation index in liver homogenate were estimated. AlCl3 treatment resulted in a significant increase in plasma AST, ALT, ALP and LDH activities with decreased total protein compared to control. AlCl3 significantly reduced superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels but increased malondialdehyde (MDA) level in the liver compared to control. AlCl3 also caused various histopathological changes in the livers of rats. Curcumin could normalize nearly all these parameters. CUR improved levels of changes in different parameters when was combined with AlCl3. It is concluded that CUR has beneficial influences being able to antagonize AlCl3 toxicity.http://pbr.mazums.ac.ir/article-1-222-en.htmlaluminum chloridecurcuminhepatotoxicityoxidative stress |
| spellingShingle | Ebrahim Cheraghi Kambiz Roshanaei The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats Pharmaceutical and Biomedical Research aluminum chloride curcumin hepatotoxicity oxidative stress |
| title | The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats |
| title_full | The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats |
| title_fullStr | The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats |
| title_full_unstemmed | The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats |
| title_short | The protective effect of curcumin against aluminum-induced oxidative stress and hepatotoxicity in male rats |
| title_sort | protective effect of curcumin against aluminum induced oxidative stress and hepatotoxicity in male rats |
| topic | aluminum chloride curcumin hepatotoxicity oxidative stress |
| url | http://pbr.mazums.ac.ir/article-1-222-en.html |
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