Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers

Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers

In part I of this review, the authors showed how poly(amidoamine) (PAMAM)-based dendrimers can be considered as promising delivering platforms for siRNA therapeutics. This is by virtue of their precise and unique multivalent molecular architecture, characterized by uniform branching units and a plet...

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Bibliographic Details
Main Authors: Erik Laurini, Domenico Marson, Suzana Aulic, Maurizio Fermeglia, Sabrina Pricl
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceutics
Subjects:
RNAi therapeutics
siRNA delivery
amphiphilic dendrons
PAMAM dendrimers
self-assembling
nanovectors
gene silencing
Online Access:https://www.mdpi.com/1999-4923/11/7/324

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