Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism
Beta adrenergic receptors are crucial for their role in rhythmic contraction of heart along with their role in the pathological conditions such as tachycardia and high risk of heart failure. Studies report that the levels of beta-1 adrenergic receptor tend to decrease by 50%, whereas, the levels of...
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MDPI AG
2016-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/10/1291 |
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| author | Kailash Singh Aung Moe Zaw Revathi Sekar Ahuja Palak Ahmed A. Allam Jamaan Ajarem Billy K. C. Chow |
| author_facet | Kailash Singh Aung Moe Zaw Revathi Sekar Ahuja Palak Ahmed A. Allam Jamaan Ajarem Billy K. C. Chow |
| author_sort | Kailash Singh |
| collection | DOAJ |
| description | Beta adrenergic receptors are crucial for their role in rhythmic contraction of heart along with their role in the pathological conditions such as tachycardia and high risk of heart failure. Studies report that the levels of beta-1 adrenergic receptor tend to decrease by 50%, whereas, the levels of beta-2 adrenergic receptor remains constant during the risk of heart failure. Beta blockers—the antagonistic molecules for beta-adrenergic receptors, function by slowing the heart rate, which thereby allows the left ventricle to fill completely during tachycardia incidents and hence helps in blood pumping capacity of heart and reducing the risk of heart failure. In the present study, we investigate the potential of glycyrrhizic acid (GA) as a possible principal drug molecule for cardiac arrhythmias owing to its ability to induce reduction in the heart rate and blood pressure. We use in vitro and in silico approach to study GA′s effect on beta adrenergic receptor along with an in vivo study to examine its effect on heart rate and blood pressure. Additionally, we explore GA′s proficiency in eliciting an increase in the plasma levels of vasoactive intestinal peptide, which by dilating the blood vessel consequently, can be a crucial aid during the occurrence of a potential heart attack. Therefore, we propose GA as a potential principal drug molecule via its potential in modulating heart rate and blood pressure. |
| first_indexed | 2024-12-10T03:40:05Z |
| format | Article |
| id | doaj.art-bf73880e2b7f4773a7b542f5ea3fd762 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T03:40:05Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bf73880e2b7f4773a7b542f5ea3fd7622022-12-22T02:03:35ZengMDPI AGMolecules1420-30492016-09-012110129110.3390/molecules21101291molecules21101291Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual MechanismKailash Singh0Aung Moe Zaw1Revathi Sekar2Ahuja Palak3Ahmed A. Allam4Jamaan Ajarem5Billy K. C. Chow6School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, ChinaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, ChinaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaSchool of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, ChinaBeta adrenergic receptors are crucial for their role in rhythmic contraction of heart along with their role in the pathological conditions such as tachycardia and high risk of heart failure. Studies report that the levels of beta-1 adrenergic receptor tend to decrease by 50%, whereas, the levels of beta-2 adrenergic receptor remains constant during the risk of heart failure. Beta blockers—the antagonistic molecules for beta-adrenergic receptors, function by slowing the heart rate, which thereby allows the left ventricle to fill completely during tachycardia incidents and hence helps in blood pumping capacity of heart and reducing the risk of heart failure. In the present study, we investigate the potential of glycyrrhizic acid (GA) as a possible principal drug molecule for cardiac arrhythmias owing to its ability to induce reduction in the heart rate and blood pressure. We use in vitro and in silico approach to study GA′s effect on beta adrenergic receptor along with an in vivo study to examine its effect on heart rate and blood pressure. Additionally, we explore GA′s proficiency in eliciting an increase in the plasma levels of vasoactive intestinal peptide, which by dilating the blood vessel consequently, can be a crucial aid during the occurrence of a potential heart attack. Therefore, we propose GA as a potential principal drug molecule via its potential in modulating heart rate and blood pressure.http://www.mdpi.com/1420-3049/21/10/1291adrenergic receptorsglycyrrhizic acidvasoactive-intestinal peptidetachycardia |
| spellingShingle | Kailash Singh Aung Moe Zaw Revathi Sekar Ahuja Palak Ahmed A. Allam Jamaan Ajarem Billy K. C. Chow Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism Molecules adrenergic receptors glycyrrhizic acid vasoactive-intestinal peptide tachycardia |
| title | Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism |
| title_full | Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism |
| title_fullStr | Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism |
| title_full_unstemmed | Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism |
| title_short | Glycyrrhizic Acid Reduces Heart Rate and Blood Pressure by a Dual Mechanism |
| title_sort | glycyrrhizic acid reduces heart rate and blood pressure by a dual mechanism |
| topic | adrenergic receptors glycyrrhizic acid vasoactive-intestinal peptide tachycardia |
| url | http://www.mdpi.com/1420-3049/21/10/1291 |
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