Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain
Weight-related disorders affect more than half of the adult population worldwide; they are also concomitant with a state of chronic low-grade inflammation manifesting in abnormal cytokine production. The present study evaluated the effect of polyphenol and flavonoid extract from Passiflora ligularis...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-06-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2021-0005 |
| _version_ | 1819000987213365248 |
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| author | Angel-Isaza Jaime Carmona-Hernandez Juan Carlos Narváez-Solarte William Gonzalez-Correa Clara Helena |
| author_facet | Angel-Isaza Jaime Carmona-Hernandez Juan Carlos Narváez-Solarte William Gonzalez-Correa Clara Helena |
| author_sort | Angel-Isaza Jaime |
| collection | DOAJ |
| description | Weight-related disorders affect more than half of the adult population worldwide; they are also concomitant with a state of chronic low-grade inflammation manifesting in abnormal cytokine production. The present study evaluated the effect of polyphenol and flavonoid extract from Passiflora ligularis (granadilla) on low-grade inflammation and body weight in overweight Wistar rats. To induce weight-gain, rats were fed a chow diet with 30% sucrose water and supplemented with 2.0, 2.5, and 3.0 g/L polyphenol extracts (n = 16). The design was a 3 +1 factorial model performed for 42 days (granadilla polyphenols, 3 levels of supplementation, and 1 control group). In addition to total polyphenol and total flavonoid content, the major identified and quantified polyphenol, via UHPLC, was ferulic acid. Interleukin 6 (IL-6), and cytokine tumor necrosis factor-alpha (TNF-α) were evaluated in serum. A decline in the concentration of TNF-α and in weight-gain was found in P. ligularis (granadilla) groups treated with the 2.5 g/L dose. Consumption of polyphenol extracts from granadilla inhibits interleukin-activity as an indicator of inflammation and aids in body-weight control, considering similar food intake, in overweight Wistar rats. |
| first_indexed | 2024-12-20T22:42:03Z |
| format | Article |
| id | doaj.art-bf73e63202df408ebb0bb5da63df8acd |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-20T22:42:03Z |
| publishDate | 2021-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-bf73e63202df408ebb0bb5da63df8acd2022-12-21T19:24:27ZengDe GruyterBiomolecular Concepts1868-50211868-503X2021-06-01121364510.1515/bmc-2021-0005Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight GainAngel-Isaza Jaime0Carmona-Hernandez Juan Carlos1Narváez-Solarte William2Gonzalez-Correa Clara Helena3Research Group on Nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, ColombiaGrupo de Investigacion Medica, Universidad de Manizales, Manizales, ColombiaResearch Group on Nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, ColombiaResearch Group on Nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, ColombiaWeight-related disorders affect more than half of the adult population worldwide; they are also concomitant with a state of chronic low-grade inflammation manifesting in abnormal cytokine production. The present study evaluated the effect of polyphenol and flavonoid extract from Passiflora ligularis (granadilla) on low-grade inflammation and body weight in overweight Wistar rats. To induce weight-gain, rats were fed a chow diet with 30% sucrose water and supplemented with 2.0, 2.5, and 3.0 g/L polyphenol extracts (n = 16). The design was a 3 +1 factorial model performed for 42 days (granadilla polyphenols, 3 levels of supplementation, and 1 control group). In addition to total polyphenol and total flavonoid content, the major identified and quantified polyphenol, via UHPLC, was ferulic acid. Interleukin 6 (IL-6), and cytokine tumor necrosis factor-alpha (TNF-α) were evaluated in serum. A decline in the concentration of TNF-α and in weight-gain was found in P. ligularis (granadilla) groups treated with the 2.5 g/L dose. Consumption of polyphenol extracts from granadilla inhibits interleukin-activity as an indicator of inflammation and aids in body-weight control, considering similar food intake, in overweight Wistar rats.https://doi.org/10.1515/bmc-2021-0005passiflora ligularis (granadilla)phenolic compoundsanti-inflammatory activityoverweight rats |
| spellingShingle | Angel-Isaza Jaime Carmona-Hernandez Juan Carlos Narváez-Solarte William Gonzalez-Correa Clara Helena Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain Biomolecular Concepts passiflora ligularis (granadilla) phenolic compounds anti-inflammatory activity overweight rats |
| title | Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain |
| title_full | Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain |
| title_fullStr | Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain |
| title_full_unstemmed | Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain |
| title_short | Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain |
| title_sort | polyphenols from passiflora ligularis regulate inflammatory markers and weight gain |
| topic | passiflora ligularis (granadilla) phenolic compounds anti-inflammatory activity overweight rats |
| url | https://doi.org/10.1515/bmc-2021-0005 |
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