Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study
Background: Exposure to ambient air pollution has been reported to be inversely correlated with human reproductive health. However, the results of previous studies exploring the association between air pollution and in vitro fertilization (IVF) outcomes are conflicting, and further research is neede...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
|
| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021001690 |
| _version_ | 1818437822845026304 |
|---|---|
| author | Shanshan Wu Yunshan Zhang Xueqing Wu Guimin Hao Haiqin Ren Jiahui Qiu Yinfeng Zhang Xingyu Bi Aimin Yang Lina Bai Jichun Tan |
| author_facet | Shanshan Wu Yunshan Zhang Xueqing Wu Guimin Hao Haiqin Ren Jiahui Qiu Yinfeng Zhang Xingyu Bi Aimin Yang Lina Bai Jichun Tan |
| author_sort | Shanshan Wu |
| collection | DOAJ |
| description | Background: Exposure to ambient air pollution has been reported to be inversely correlated with human reproductive health. However, the results of previous studies exploring the association between air pollution and in vitro fertilization (IVF) outcomes are conflicting, and further research is needed to clarify this association. Objectives: This study aimed to investigate the associations between exposure to air pollutants and IVF outcomes. Methods: We conducted a multicenter retrospective cohort study involving 20,835 patients from four cities in Northern China, contributing to 11,787 fresh embryo transfer cycles, 9050 freeze-all cycles, and 17,676 frozen-thawed embryo transfer (FET) cycles during 2014–2018. We calculated the daily average concentrations of six criteria air pollutants (PM2.5, PM10, O3, NO2, CO, and SO2) during different exposure windows in IVF treatment timeline using data from the air monitoring station nearest to the residential site as approximate individual exposure. Generalized estimation equation models were used to assess the association between air pollution exposure and IVF outcomes. Results: Exposure to O3, NO2, and CO during most exposure windows in fresh embryo transfer cycles were correlated with lower possibilities of biochemical pregnancy, clinical pregnancy, and live birth. An inverse association of exposure to O3 and SO2 with pregnancy outcomes was observed in FET cycles. In addition, we found a significant association of exposure to air pollutants with a higher risk of ectopic pregnancy and lower oocyte yield. Conclusions: Our study provided large-scale human evidence of the association between air pollution and adverse human reproductive outcomes in the population opting for IVF. Thus, exposure to air pollutants in the population opting for IVF should be limited to improve treatment outcomes. |
| first_indexed | 2024-12-14T17:30:47Z |
| format | Article |
| id | doaj.art-bf749a2be03c4da69332957096a65a52 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-14T17:30:47Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-bf749a2be03c4da69332957096a65a522022-12-21T22:53:06ZengElsevierEnvironment International0160-41202021-08-01153106544Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective studyShanshan Wu0Yunshan Zhang1Xueqing Wu2Guimin Hao3Haiqin Ren4Jiahui Qiu5Yinfeng Zhang6Xingyu Bi7Aimin Yang8Lina Bai9Jichun Tan10Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodeling of Liaoning Province, PR ChinaTianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300100, PR ChinaCenter of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030013, PR ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR ChinaJinghua Hospital, Shenyang, Liaoning 110022, PR ChinaCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodeling of Liaoning Province, PR ChinaTianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300100, PR ChinaCenter of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030013, PR ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR ChinaJinghua Hospital, Shenyang, Liaoning 110022, PR ChinaCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China; Key Laboratory of Reproductive Dysfunction Disease and Fertility Remodeling of Liaoning Province, PR China; Corresponding author at: Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No.39 Huaxiang Road, Tiexi District, Shenyang, Liaoning 110022, PR China.Background: Exposure to ambient air pollution has been reported to be inversely correlated with human reproductive health. However, the results of previous studies exploring the association between air pollution and in vitro fertilization (IVF) outcomes are conflicting, and further research is needed to clarify this association. Objectives: This study aimed to investigate the associations between exposure to air pollutants and IVF outcomes. Methods: We conducted a multicenter retrospective cohort study involving 20,835 patients from four cities in Northern China, contributing to 11,787 fresh embryo transfer cycles, 9050 freeze-all cycles, and 17,676 frozen-thawed embryo transfer (FET) cycles during 2014–2018. We calculated the daily average concentrations of six criteria air pollutants (PM2.5, PM10, O3, NO2, CO, and SO2) during different exposure windows in IVF treatment timeline using data from the air monitoring station nearest to the residential site as approximate individual exposure. Generalized estimation equation models were used to assess the association between air pollution exposure and IVF outcomes. Results: Exposure to O3, NO2, and CO during most exposure windows in fresh embryo transfer cycles were correlated with lower possibilities of biochemical pregnancy, clinical pregnancy, and live birth. An inverse association of exposure to O3 and SO2 with pregnancy outcomes was observed in FET cycles. In addition, we found a significant association of exposure to air pollutants with a higher risk of ectopic pregnancy and lower oocyte yield. Conclusions: Our study provided large-scale human evidence of the association between air pollution and adverse human reproductive outcomes in the population opting for IVF. Thus, exposure to air pollutants in the population opting for IVF should be limited to improve treatment outcomes.http://www.sciencedirect.com/science/article/pii/S0160412021001690Air pollutionIn vitro fertilizationPregnancy rateLive birthEctopic pregnancy |
| spellingShingle | Shanshan Wu Yunshan Zhang Xueqing Wu Guimin Hao Haiqin Ren Jiahui Qiu Yinfeng Zhang Xingyu Bi Aimin Yang Lina Bai Jichun Tan Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study Environment International Air pollution In vitro fertilization Pregnancy rate Live birth Ectopic pregnancy |
| title | Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study |
| title_full | Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study |
| title_fullStr | Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study |
| title_full_unstemmed | Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study |
| title_short | Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study |
| title_sort | association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment a multicenter retrospective study |
| topic | Air pollution In vitro fertilization Pregnancy rate Live birth Ectopic pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021001690 |
| work_keys_str_mv | AT shanshanwu associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT yunshanzhang associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT xueqingwu associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT guiminhao associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT haiqinren associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT jiahuiqiu associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT yinfengzhang associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT xingyubi associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT aiminyang associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT linabai associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy AT jichuntan associationbetweenexposuretoambientairpollutantsandtheoutcomesofinvitrofertilizationtreatmentamulticenterretrospectivestudy |