Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole
The aim of this paper, the synthesis of new series of substituted 1,3,4-thaidiazole and 1,2,4-triazol from reaction of the carboxylic acid (2-naphthoic acid,4-methyl benzoic acid) with absolute ethanol in the presence of concentrated sulfuric acid to give esters. the above synthesis ester were conve...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
2020-03-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_164384_d41d8cd98f00b204e9800998ecf8427e.pdf |
| _version_ | 1818310064842211328 |
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| author | Tamara alsafar amal Ali |
| author_facet | Tamara alsafar amal Ali |
| author_sort | Tamara alsafar |
| collection | DOAJ |
| description | The aim of this paper, the synthesis of new series of substituted 1,3,4-thaidiazole and 1,2,4-triazol from reaction of the carboxylic acid (2-naphthoic acid,4-methyl benzoic acid) with absolute ethanol in the presence of concentrated sulfuric acid to give esters. the above synthesis ester were converted to acid hydrazide by their reaction with hydrazine hydrate in ethanol, which then reacted with ammonium thiocyanate and hydrochloric acid in ethanol or with phenylisothiocyanate in absolute ethanol to give substituted thiosemicarbazides compounds. the substituted thiosemicarbazides then uses to synthesis of many hyterocyclic compounds like substituted 1,3,4-thiadiazole and 1,2,4-triazole by its reaction with concentrated sulfuric acid and sodium hydroxide respectively. the substituted thiosemicarbazides then cyclization to substituted 3,4-diamine-1,2,4-triazole when treated with hydrazine hydrate. And finally the N- acetyl-N-substituted hydrazide compounds synthesis by treated hydrazide with acetyl chloride in anhydrous tetrahydrofuran which then cyclized to 2-methyl substituted-1,2,4-thiadiazole by their reaction with diphosphorus pentoxide in xylene. The structure of the synthesized compounds were confirmed By physcical & spectroscopic techniques infrared (IR) and (1H-NMR) data. |
| first_indexed | 2024-12-13T07:40:08Z |
| format | Article |
| id | doaj.art-bf74c303afdc47d18bda07f228c584a4 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-13T07:40:08Z |
| publishDate | 2020-03-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-bf74c303afdc47d18bda07f228c584a42022-12-21T23:54:59ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302020-03-01291435910.33899/edusj.2019.125949.1008164384Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-TriazoleTamara alsafar0amal Ali1Department of Chemistry, College of Education for Pure Science, University of Mosul, Iraq.Department of Chemistry, College of Education for Pure Science, University of Mosul, Iraq.The aim of this paper, the synthesis of new series of substituted 1,3,4-thaidiazole and 1,2,4-triazol from reaction of the carboxylic acid (2-naphthoic acid,4-methyl benzoic acid) with absolute ethanol in the presence of concentrated sulfuric acid to give esters. the above synthesis ester were converted to acid hydrazide by their reaction with hydrazine hydrate in ethanol, which then reacted with ammonium thiocyanate and hydrochloric acid in ethanol or with phenylisothiocyanate in absolute ethanol to give substituted thiosemicarbazides compounds. the substituted thiosemicarbazides then uses to synthesis of many hyterocyclic compounds like substituted 1,3,4-thiadiazole and 1,2,4-triazole by its reaction with concentrated sulfuric acid and sodium hydroxide respectively. the substituted thiosemicarbazides then cyclization to substituted 3,4-diamine-1,2,4-triazole when treated with hydrazine hydrate. And finally the N- acetyl-N-substituted hydrazide compounds synthesis by treated hydrazide with acetyl chloride in anhydrous tetrahydrofuran which then cyclized to 2-methyl substituted-1,2,4-thiadiazole by their reaction with diphosphorus pentoxide in xylene. The structure of the synthesized compounds were confirmed By physcical & spectroscopic techniques infrared (IR) and (1H-NMR) data.https://edusj.mosuljournals.com/article_164384_d41d8cd98f00b204e9800998ecf8427e.pdfhyterocyclic,,,،,؛thiadiazole,,,،,؛triazole,,,،,؛thiosemicarbazide |
| spellingShingle | Tamara alsafar amal Ali Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole مجلة التربية والعلم hyterocyclic,, ,،,؛thiadiazole,, ,،,؛triazole,, ,،,؛thiosemicarbazide |
| title | Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole |
| title_full | Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole |
| title_fullStr | Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole |
| title_full_unstemmed | Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole |
| title_short | Synthesis Some of New Substituted 1,3,4-Thiadiazole and 1,2,4-Triazole |
| title_sort | synthesis some of new substituted 1 3 4 thiadiazole and 1 2 4 triazole |
| topic | hyterocyclic,, ,،,؛thiadiazole,, ,،,؛triazole,, ,،,؛thiosemicarbazide |
| url | https://edusj.mosuljournals.com/article_164384_d41d8cd98f00b204e9800998ecf8427e.pdf |
| work_keys_str_mv | AT tamaraalsafar synthesissomeofnewsubstituted134thiadiazoleand124triazole AT amalali synthesissomeofnewsubstituted134thiadiazoleand124triazole |