Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples
Vibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical “fingerprint” with a unique signature profile. Nuclear magnetic resonance (NMR) sp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/20/4725 |
| _version_ | 1797550959676620800 |
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| author | Kevin V. Hackshaw Joseph S. Miller Didem P. Aykas Luis Rodriguez-Saona |
| author_facet | Kevin V. Hackshaw Joseph S. Miller Didem P. Aykas Luis Rodriguez-Saona |
| author_sort | Kevin V. Hackshaw |
| collection | DOAJ |
| description | Vibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical “fingerprint” with a unique signature profile. Nuclear magnetic resonance (NMR) spectroscopy and an array of mass spectrometry (MS) techniques provide selectivity and specificity for screening metabolites, but demand costly instrumentation, complex sample pretreatment, are labor-intensive, require well-trained technicians to operate the instrumentation, and are less amenable for implementation in clinics. The potential for vibration spectroscopy techniques to be brought to the bedside gives hope for huge cost savings and potential revolutionary advances in diagnostics in the clinic. We discuss the utilization of current vibrational spectroscopy methodologies on biologic samples as an avenue towards rapid cost saving diagnostics. |
| first_indexed | 2024-03-10T15:36:48Z |
| format | Article |
| id | doaj.art-bf7531a5e0b94d62925c7f8814bae6a3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:36:48Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bf7531a5e0b94d62925c7f8814bae6a32023-11-20T17:10:45ZengMDPI AGMolecules1420-30492020-10-012520472510.3390/molecules25204725Vibrational Spectroscopy for Identification of Metabolites in Biologic SamplesKevin V. Hackshaw0Joseph S. Miller1Didem P. Aykas2Luis Rodriguez-Saona3Department of Internal Medicine, Division of Rheumatology, Dell Medical School, The University of Texas, 1601 Trinity St, Austin, TX 78712, USADepartment of Medicine, Ohio University Heritage College of Osteopathic Medicine, Dublin, OH 43016, USADepartment of Food Science and Technology, Ohio State University, Columbus, OH 43210, USADepartment of Food Science and Technology, Ohio State University, Columbus, OH 43210, USAVibrational spectroscopy (mid-infrared (IR) and Raman) and its fingerprinting capabilities offer rapid, high-throughput, and non-destructive analysis of a wide range of sample types producing a characteristic chemical “fingerprint” with a unique signature profile. Nuclear magnetic resonance (NMR) spectroscopy and an array of mass spectrometry (MS) techniques provide selectivity and specificity for screening metabolites, but demand costly instrumentation, complex sample pretreatment, are labor-intensive, require well-trained technicians to operate the instrumentation, and are less amenable for implementation in clinics. The potential for vibration spectroscopy techniques to be brought to the bedside gives hope for huge cost savings and potential revolutionary advances in diagnostics in the clinic. We discuss the utilization of current vibrational spectroscopy methodologies on biologic samples as an avenue towards rapid cost saving diagnostics.https://www.mdpi.com/1420-3049/25/20/4725vibrational spectroscopyRaman spectroscopyinfrared spectroscopyfingerprintingmetabolitesspectroscopy |
| spellingShingle | Kevin V. Hackshaw Joseph S. Miller Didem P. Aykas Luis Rodriguez-Saona Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples Molecules vibrational spectroscopy Raman spectroscopy infrared spectroscopy fingerprinting metabolites spectroscopy |
| title | Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples |
| title_full | Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples |
| title_fullStr | Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples |
| title_full_unstemmed | Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples |
| title_short | Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples |
| title_sort | vibrational spectroscopy for identification of metabolites in biologic samples |
| topic | vibrational spectroscopy Raman spectroscopy infrared spectroscopy fingerprinting metabolites spectroscopy |
| url | https://www.mdpi.com/1420-3049/25/20/4725 |
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