Novel high‐affinity EGFRvIII‐specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

Novel high‐affinity EGFRvIII‐specific chimeric antigen receptor T cells effectively eliminate human glioblastoma

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Abstract Objectives The increasing success of Chimeric Antigen Receptor (CAR) T cell therapy in haematological malignancies is reinvigorating its application in many other cancer types and with renewed focus on its application to solid tumors. We present a novel CAR against glioblastoma, an aggressi...

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Bibliographic Details
Main Authors: Rebecca C Abbott, Daniel J Verdon, Fiona M Gracey, Hannah E Hughes‐Parry, Melinda Iliopoulos, Katherine A Watson, Matthias Mulazzani, Kylie Luong, Colleen D’Arcy, Lucy C Sullivan, Ben R Kiefel, Ryan S Cross, Misty R Jenkins
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
Chimeric Antigen Receptor (CAR)
T cells
CAR T cells
EGFRvIII
glioblastoma
immunotherapy
Online Access:https://doi.org/10.1002/cti2.1283

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