Inhibiting the NLRP3 Inflammasome

Inhibiting the NLRP3 Inflammasome

Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicab...

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Bibliographic Details
Main Authors: Lina Y. El-Sharkawy, David Brough, Sally Freeman
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
inflammation
NLRP3
inflammasome
cytokine
cryo-EM
drug discovery
Online Access:https://www.mdpi.com/1420-3049/25/23/5533

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