ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS
Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2018-06-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1559 |
| _version_ | 1797197975113433088 |
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| author | M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov |
| author_facet | M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov |
| author_sort | M. V. Kiselevsky |
| collection | DOAJ |
| description | Ability of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneration. |
| first_indexed | 2024-03-08T05:49:03Z |
| format | Article |
| id | doaj.art-bf77f7a4aea3429c8b14205dd82bb443 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:30Z |
| publishDate | 2018-06-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-bf77f7a4aea3429c8b14205dd82bb4432024-04-22T13:07:43ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2018-06-0120451552210.15789/1563-0625-2018-4-515-5221026ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTSM. V. Kiselevsky0N. Yu. Anisimova1Yu. I. Dolzhikova2R. Ya. Vlasenko3F. S. Senatov4A. V. Karaulov5N.N. Blokhin National Medical Center of OncologyN.N. Blokhin National Medical Center of Oncology; National University of Science and Technology MISiSNational University of Science and Technology MISiSN.N. Blokhin National Medical Center of OncologyNational University of Science and Technology MISiSI.M. Sechenov First Moscow State Medical UniversityAbility of mesenchymal multipotent stromal cells (MSCs) to differentiate into several types of mesenchymal tissues allows to consider these cells the main candidates for creating tissue engineering constructions for regenerative medicine. MSCs promote integration of bio-implants into the native bone and stimulate osteogenesis. MSCs are characterized by immunomodulatory properties, due to inflammation control and modification of immune cells. MSCs affect not only the in vivo immune response by preventing immunological rejection of implanted tissue engineering designs, but it can also influence the bone tissue immunity. MSCs play an important role in bone regeneration, by regulating the osteoblastic generation, and suppressing activity of inflammation effectors and osteoclastogenesis. Some pre-clinical and first clinical trials of bone bio-implants colonized with MSC, demonstrate promising outlooks for this strategy in order to obtain tissue engineering constructions for bone regeneration.https://www.mimmun.ru/mimmun/article/view/1559mesenchymal multipotent stromal cellsimmunomodulating activitybone bioimplantsosteoimmunologytissue engineering constructions |
| spellingShingle | M. V. Kiselevsky N. Yu. Anisimova Yu. I. Dolzhikova R. Ya. Vlasenko F. S. Senatov A. V. Karaulov ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS Медицинская иммунология mesenchymal multipotent stromal cells immunomodulating activity bone bioimplants osteoimmunology tissue engineering constructions |
| title | ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS |
| title_full | ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS |
| title_fullStr | ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS |
| title_full_unstemmed | ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS |
| title_short | ROLE OF MESENCHYMAL MULTIPOTENT STROMAL CELLS IN REMODELING OF BONE DEFECTS |
| title_sort | role of mesenchymal multipotent stromal cells in remodeling of bone defects |
| topic | mesenchymal multipotent stromal cells immunomodulating activity bone bioimplants osteoimmunology tissue engineering constructions |
| url | https://www.mimmun.ru/mimmun/article/view/1559 |
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