MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

Myotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the mismatch repair (MMR) proteins MSH2 and MSH3, forming the MutSbeta complex. It has...

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Bibliographic Details
Main Authors: Stéphanie Tomé, Ian Holt, Winfried Edelmann, Glenn E Morris, Arnold Munnich, Christopher E Pearson, Geneviève Gourdon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2674216?pdf=render

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