Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn’s colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling

Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn’s colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling

Abstract Background Inflammatory bowel diseases (IBD) are chronic relapsing–remitting inflammatory diseases of the gastrointestinal tract that are typically categorized into two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). Although MSCs therapy has achieved encouraging outcomes i...

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Bibliographic Details
Main Authors: Yixin Ye, Xiaomei Zhang, Dongsheng Su, Yushuang Ren, Fuyi Cheng, Yunqi Yao, Gang Shi, Yanhong Ji, Shuang Chen, Pengyi Shi, Lei Dai, Xiaolan Su, Hongxin Deng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
Human adipose tissue-derived MSCs
Pretreated hADSCs with IFN-γ and KYNA
Crohn’s disease colonic fibrosis rat model
Indoleamine 2,3-dioxygenase-1
Online Access:https://doi.org/10.1186/s13287-022-03157-8

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