The pathogenesis of HIV infection: stupid may not be so dumb after all
<p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathoge...
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| Format: | Article |
| Language: | English |
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BMC
2006-09-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/3/1/60 |
| _version_ | 1811252530552766464 |
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| author | Smith Stephen M |
| author_facet | Smith Stephen M |
| author_sort | Smith Stephen M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4<sup>+ </sup>T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.</p> |
| first_indexed | 2024-04-12T16:35:59Z |
| format | Article |
| id | doaj.art-bf7cd9c4fa7f4fbaac9f52822bbf1176 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-12T16:35:59Z |
| publishDate | 2006-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-bf7cd9c4fa7f4fbaac9f52822bbf11762022-12-22T03:25:00ZengBMCRetrovirology1742-46902006-09-01316010.1186/1742-4690-3-60The pathogenesis of HIV infection: stupid may not be so dumb after allSmith Stephen M<p>Abstract</p> <p>In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4<sup>+ </sup>T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4<sup>+ </sup>T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.</p>http://www.retrovirology.com/content/3/1/60 |
| spellingShingle | Smith Stephen M The pathogenesis of HIV infection: stupid may not be so dumb after all Retrovirology |
| title | The pathogenesis of HIV infection: stupid may not be so dumb after all |
| title_full | The pathogenesis of HIV infection: stupid may not be so dumb after all |
| title_fullStr | The pathogenesis of HIV infection: stupid may not be so dumb after all |
| title_full_unstemmed | The pathogenesis of HIV infection: stupid may not be so dumb after all |
| title_short | The pathogenesis of HIV infection: stupid may not be so dumb after all |
| title_sort | pathogenesis of hiv infection stupid may not be so dumb after all |
| url | http://www.retrovirology.com/content/3/1/60 |
| work_keys_str_mv | AT smithstephenm thepathogenesisofhivinfectionstupidmaynotbesodumbafterall AT smithstephenm pathogenesisofhivinfectionstupidmaynotbesodumbafterall |