The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1

Abstract Background Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 (SF3B1 R625H ), but its functional effects and underlying molecular mechanisms remain largely unexplored. Methods Using the CRISPR/Cas9 genome editing system and rat pituitary GH3 cells, we...

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Bibliographic Details
Main Authors: Jing Guo, Chuzhong Li, Qiuyue Fang, Yulou Liu, Dawei Wang, Yiyuan Chen, Weiyan Xie, Yazhuo Zhang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SF3B1 mutation
Prolactinomas
Alternative splicing
DLG1
Invasion
Online Access:https://doi.org/10.1186/s13046-022-02245-0

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