Unraveling axonal mechanisms of traumatic brain injury

Unraveling axonal mechanisms of traumatic brain injury

Abstract Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current evidence proposes a role of perturbed Ca2+ homeostasis in AS formation, involving impaired axonal transport and focal distension of the axons. Mech...

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Bibliographic Details
Main Authors: Victorio M. Pozo Devoto, Valentina Lacovich, Monica Feole, Pratiksha Bhat, Jaroslav Chovan, Maria Čarna, Isaac G. Onyango, Neda Dragišić, Martina Sűsserová, Martin E. Barrios-Llerena, Gorazd B. Stokin
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Axonal swellings
Traumatic brain injury
Calcium
Microtubules
Subcortical periodic cytoskeleton
Phosphoproteomics
Online Access:https://doi.org/10.1186/s40478-022-01414-8

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