The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils

The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils

Summary: Background: IgE-mediated hypersensitivity is becoming increasingly prevalent and activation of mast cells and basophils represent key events in the pathophysiology of allergy. We have previously reported that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) exerts...

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Bibliographic Details
Main Authors: Maria Laggner, Gabriela Sánchez Acosta, Claudia Kitzmüller, Dragan Copic, Florian Gruber, Lukas Matthäus Altenburger, Vera Vorstandlechner, Alfred Gugerell, Martin Direder, Katharina Klas, Daniel Bormann, Anja Peterbauer, Akira Shibuya, Barbara Bohle, Hendrik Jan Ankersmit, Michael Mildner
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:EBioMedicine
Subjects:
Anti-allergic therapeutic secretome
Basophil activation
Birch pollen allergy
Mast cell degranulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422002742

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