Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma
Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. Howev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2017-07-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320317717904 |
| _version_ | 1797281970406817792 |
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| author | Yan-Ye Su Chang-Han Chen Chih-Yen Chien Wei-Che Lin Wan-Ting Huang Shau-Hsuan Li |
| author_facet | Yan-Ye Su Chang-Han Chen Chih-Yen Chien Wei-Che Lin Wan-Ting Huang Shau-Hsuan Li |
| author_sort | Yan-Ye Su |
| collection | DOAJ |
| description | Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma. Methods: Mitochondrial assembly receptor immunohistochemistry was examined in 151 oral tongue squamous cell carcinoma patients and was correlated with treatment outcome. The functional relevance of the mitochondrial assembly receptor in oral tongue squamous cell carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide reduction and bromodeoxyuridine incorporation assays. Results: Mitochondrial assembly receptor overexpression was significantly correlated with early pathological T classification ( p =0.029) and the absence of extracapsular spread ( p =0.039). Univariate analyses demonstrated that mitochondrial assembly receptor overexpression was significantly associated with superior overall survival ( p =0.012). In multivariate comparison, mitochondrial assembly receptor overexpression remained independently associated with superior overall survival ( p =0.008, hazard ratio=1.862). In vitro, angiotensin-(1-7) suppressed the cell growth in oral tongue squamous cell carcinoma cells, and this response was reversed by the mitochondrial assembly receptor antagonist, A779. Conclusion: Mitochondrial assembly receptor expression is independently associated with the prognosis of oral tongue squamous cell carcinoma patients. These findings suggest that mitochondrial assembly receptor signaling may be a promising novel target for oral tongue squamous cell carcinoma. |
| first_indexed | 2024-03-07T17:04:10Z |
| format | Article |
| id | doaj.art-bf807efd93b24054affdc091fe1f573f |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:04:10Z |
| publishDate | 2017-07-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-bf807efd93b24054affdc091fe1f573f2024-03-03T02:50:23ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762017-07-011810.1177/1470320317717904Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinomaYan-Ye Su0Chang-Han Chen1Chih-Yen Chien2Wei-Che Lin3Wan-Ting Huang4Shau-Hsuan Li5Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.Department of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.Department of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C.Introduction: Recent evidence suggests that the local renin-angiotensin system has been implicated in various malignancies. The mitochondrial assembly receptor is a newly identified receptor for angiotensin peptides, angiotensin-(1-7), and has an important role in the renin-angiotensin system. However, the role of the mitochondrial assembly receptor in the prognosis of cancer patients remains unclear. The aim of this study was to evaluate the significance of mitochondrial assembly receptor signaling in the prognosis of oral tongue squamous cell carcinoma. Methods: Mitochondrial assembly receptor immunohistochemistry was examined in 151 oral tongue squamous cell carcinoma patients and was correlated with treatment outcome. The functional relevance of the mitochondrial assembly receptor in oral tongue squamous cell carcinoma cell lines was evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide reduction and bromodeoxyuridine incorporation assays. Results: Mitochondrial assembly receptor overexpression was significantly correlated with early pathological T classification ( p =0.029) and the absence of extracapsular spread ( p =0.039). Univariate analyses demonstrated that mitochondrial assembly receptor overexpression was significantly associated with superior overall survival ( p =0.012). In multivariate comparison, mitochondrial assembly receptor overexpression remained independently associated with superior overall survival ( p =0.008, hazard ratio=1.862). In vitro, angiotensin-(1-7) suppressed the cell growth in oral tongue squamous cell carcinoma cells, and this response was reversed by the mitochondrial assembly receptor antagonist, A779. Conclusion: Mitochondrial assembly receptor expression is independently associated with the prognosis of oral tongue squamous cell carcinoma patients. These findings suggest that mitochondrial assembly receptor signaling may be a promising novel target for oral tongue squamous cell carcinoma.https://doi.org/10.1177/1470320317717904 |
| spellingShingle | Yan-Ye Su Chang-Han Chen Chih-Yen Chien Wei-Che Lin Wan-Ting Huang Shau-Hsuan Li Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma Journal of the Renin-Angiotensin-Aldosterone System |
| title | Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| title_full | Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| title_fullStr | Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| title_full_unstemmed | Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| title_short | Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| title_sort | mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma |
| url | https://doi.org/10.1177/1470320317717904 |
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