Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents
The Diels–Alder reaction (DAR) is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings, and it is widely used in the synthesis of organic molecules and drugs. Due to the high regio- and stereo-selectivity and its versatility, DARs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/12/2/150 |
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| author | Alessandro Grillo Bruno Mattia Bizzarri |
| author_facet | Alessandro Grillo Bruno Mattia Bizzarri |
| author_sort | Alessandro Grillo |
| collection | DOAJ |
| description | The Diels–Alder reaction (DAR) is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings, and it is widely used in the synthesis of organic molecules and drugs. Due to the high regio- and stereo-selectivity and its versatility, DARs have represented a powerful tool for organic chemistry for many years. In addition, the asymmetric DAR has become a fundamental synthetic approach in the preparation of optically active six-membered rings and natural compounds. The COVID-19-related pandemic requires continuous research; DAR represents an useful method to obtain optically active intermediates for the synthesis of antiviral agents under different catalytic conditions. We would like to highlight an intriguing synthetic procedure applied to the development of novel synthetic protocols that are potentially useful against a large panel of viruses and other unmet diseases. |
| first_indexed | 2024-03-09T22:22:32Z |
| format | Article |
| id | doaj.art-bf80a42a563f4afe92fb56a44ea3abf4 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-09T22:22:32Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-bf80a42a563f4afe92fb56a44ea3abf42023-11-23T19:12:05ZengMDPI AGCatalysts2073-43442022-01-0112215010.3390/catal12020150Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral AgentsAlessandro Grillo0Bruno Mattia Bizzarri1Promidis (IRBM Group), Via Olgettina 60, Torre San Michele 1, Ospedale San Raffaele, 20132 Milano, ItalyBiological and Ecological Sciences Department (DEB), University of Tuscia, 01100 Viterbo, ItalyThe Diels–Alder reaction (DAR) is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings, and it is widely used in the synthesis of organic molecules and drugs. Due to the high regio- and stereo-selectivity and its versatility, DARs have represented a powerful tool for organic chemistry for many years. In addition, the asymmetric DAR has become a fundamental synthetic approach in the preparation of optically active six-membered rings and natural compounds. The COVID-19-related pandemic requires continuous research; DAR represents an useful method to obtain optically active intermediates for the synthesis of antiviral agents under different catalytic conditions. We would like to highlight an intriguing synthetic procedure applied to the development of novel synthetic protocols that are potentially useful against a large panel of viruses and other unmet diseases.https://www.mdpi.com/2073-4344/12/2/150Diels–Alder reaction (DAR)enantioselective catalysissix-membered ringantiviral agentsSARS-CoV-2COVID-19 |
| spellingShingle | Alessandro Grillo Bruno Mattia Bizzarri Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents Catalysts Diels–Alder reaction (DAR) enantioselective catalysis six-membered ring antiviral agents SARS-CoV-2 COVID-19 |
| title | Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents |
| title_full | Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents |
| title_fullStr | Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents |
| title_full_unstemmed | Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents |
| title_short | Catalytic Enantioselective Diels Alder Reaction: Application in the Synthesis of Antiviral Agents |
| title_sort | catalytic enantioselective diels alder reaction application in the synthesis of antiviral agents |
| topic | Diels–Alder reaction (DAR) enantioselective catalysis six-membered ring antiviral agents SARS-CoV-2 COVID-19 |
| url | https://www.mdpi.com/2073-4344/12/2/150 |
| work_keys_str_mv | AT alessandrogrillo catalyticenantioselectivedielsalderreactionapplicationinthesynthesisofantiviralagents AT brunomattiabizzarri catalyticenantioselectivedielsalderreactionapplicationinthesynthesisofantiviralagents |