Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy
Progress in cancer stem cells has opened up a new window to develop better cancer treatment methods. Several pre-clinical and clinical trial studies use CSCs targeting via surface markers method and inhibition of stem cell pathway to eradicate cancer. Albite, some important question was unclear abo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-05-01
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| Series: | Basic & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/398 |
| _version_ | 1798037479131971584 |
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| author | Elham Bahrami Salehloo Najme Mozdoori Mohammad javad Dehghan Esmatabadi Samira Hajigholami Ali Bozorgmehr |
| author_facet | Elham Bahrami Salehloo Najme Mozdoori Mohammad javad Dehghan Esmatabadi Samira Hajigholami Ali Bozorgmehr |
| author_sort | Elham Bahrami Salehloo |
| collection | DOAJ |
| description |
Progress in cancer stem cells has opened up a new window to develop better cancer treatment methods. Several pre-clinical and clinical trial studies use CSCs targeting via surface markers method and inhibition of stem cell pathway to eradicate cancer. Albite, some important question was unclear about CSCs origin and molecular mechanism of self-renewal, the structure of CSCs markers and so on, but the eradication of these cells eliminate cancer. In this review, we have argued about the CSC surface markers on different cancers, the mechanisms of action, and therapeutic procedures related to the cancer biomarkers. Then, we have discussed the challenges of these therapies.
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| first_indexed | 2024-04-11T21:27:06Z |
| format | Article |
| id | doaj.art-bf84f94009454124a65b29733d06dd86 |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-04-11T21:27:06Z |
| publishDate | 2022-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-bf84f94009454124a65b29733d06dd862022-12-22T04:02:22ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662022-05-01133Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapyElham Bahrami Salehloo0Najme Mozdoori1Mohammad javad Dehghan Esmatabadi2Samira Hajigholami3Ali Bozorgmehr4National Institute of Genetic Engineering and Biotechnology, Tehran, IranEstahban higher education center, Department of cellular and molecular biology, Shiraz, IranMalek - Ashtar University of Technology, Tehran, IranDepartment of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IranIran Psychiatric Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran Progress in cancer stem cells has opened up a new window to develop better cancer treatment methods. Several pre-clinical and clinical trial studies use CSCs targeting via surface markers method and inhibition of stem cell pathway to eradicate cancer. Albite, some important question was unclear about CSCs origin and molecular mechanism of self-renewal, the structure of CSCs markers and so on, but the eradication of these cells eliminate cancer. In this review, we have argued about the CSC surface markers on different cancers, the mechanisms of action, and therapeutic procedures related to the cancer biomarkers. Then, we have discussed the challenges of these therapies. https://bccr.tums.ac.ir/index.php/bccrj/article/view/398cancer stem cells (CSCs); Cancer therapy; Prognostic markers |
| spellingShingle | Elham Bahrami Salehloo Najme Mozdoori Mohammad javad Dehghan Esmatabadi Samira Hajigholami Ali Bozorgmehr Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy Basic & Clinical Cancer Research cancer stem cells (CSCs); Cancer therapy; Prognostic markers |
| title | Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy |
| title_full | Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy |
| title_fullStr | Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy |
| title_full_unstemmed | Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy |
| title_short | Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy |
| title_sort | cancer stem cell biomarkers critical roles challenges clinical applications and perspectives in cancer therapy |
| topic | cancer stem cells (CSCs); Cancer therapy; Prognostic markers |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/398 |
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