Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications
Co-crystallization of kojic acid (HKA) with silver(I), copper(II), zinc(II), or gallium(III) salts yielded three 1D coordination polymers and one 0D complex in which kojic acid was present as a neutral or anionic terminal or bridging ligand. All reactions were conducted mechanochemically via ball mi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1244 |
| _version_ | 1797623785383264256 |
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| author | Renren Sun Lucia Casali Raymond J. Turner Dario Braga Fabrizia Grepioni |
| author_facet | Renren Sun Lucia Casali Raymond J. Turner Dario Braga Fabrizia Grepioni |
| author_sort | Renren Sun |
| collection | DOAJ |
| description | Co-crystallization of kojic acid (HKA) with silver(I), copper(II), zinc(II), or gallium(III) salts yielded three 1D coordination polymers and one 0D complex in which kojic acid was present as a neutral or anionic terminal or bridging ligand. All reactions were conducted mechanochemically via ball milling and manual grinding, or via slurry. All solids were fully characterized via single-crystal and/or powder X-ray diffraction. As kojic acid is a mild antimicrobial compound that is widely used in cosmetics, and the metal cations possess antibacterial properties, their combinations were tested for potential antibacterial applications. The minimal inhibition concentrations (MICs) and minimal biocidal concentrations (MBCs) for all compounds were measured against standard strains of the bacteria <i>P. aeruginosa</i>, <i>S. aureus</i>, and <i>E. coli</i>. All compounds exerted appreciable antimicrobial activity in the order of silver, zinc, copper, and gallium complexes. |
| first_indexed | 2024-03-11T09:33:41Z |
| format | Article |
| id | doaj.art-bf85dd96b9534ce1b50d74c82d8db39d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:33:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bf85dd96b9534ce1b50d74c82d8db39d2023-11-16T17:29:41ZengMDPI AGMolecules1420-30492023-01-01283124410.3390/molecules28031244Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial ApplicationsRenren Sun0Lucia Casali1Raymond J. Turner2Dario Braga3Fabrizia Grepioni4Dipartimento di Chimica “Giacomo Ciamician”, Università di Bologna, 40126 Bologna, ItalyDipartimento di Chimica “Giacomo Ciamician”, Università di Bologna, 40126 Bologna, ItalyDepartment of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, CanadaDipartimento di Chimica “Giacomo Ciamician”, Università di Bologna, 40126 Bologna, ItalyDipartimento di Chimica “Giacomo Ciamician”, Università di Bologna, 40126 Bologna, ItalyCo-crystallization of kojic acid (HKA) with silver(I), copper(II), zinc(II), or gallium(III) salts yielded three 1D coordination polymers and one 0D complex in which kojic acid was present as a neutral or anionic terminal or bridging ligand. All reactions were conducted mechanochemically via ball milling and manual grinding, or via slurry. All solids were fully characterized via single-crystal and/or powder X-ray diffraction. As kojic acid is a mild antimicrobial compound that is widely used in cosmetics, and the metal cations possess antibacterial properties, their combinations were tested for potential antibacterial applications. The minimal inhibition concentrations (MICs) and minimal biocidal concentrations (MBCs) for all compounds were measured against standard strains of the bacteria <i>P. aeruginosa</i>, <i>S. aureus</i>, and <i>E. coli</i>. All compounds exerted appreciable antimicrobial activity in the order of silver, zinc, copper, and gallium complexes.https://www.mdpi.com/1420-3049/28/3/1244antimicrobialsantimicrobial metalssilvercoppergalliumzinc |
| spellingShingle | Renren Sun Lucia Casali Raymond J. Turner Dario Braga Fabrizia Grepioni Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications Molecules antimicrobials antimicrobial metals silver copper gallium zinc |
| title | Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications |
| title_full | Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications |
| title_fullStr | Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications |
| title_full_unstemmed | Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications |
| title_short | Exploring the Co-Crystallization of Kojic Acid with Silver(I), Copper(II), Zinc(II), and Gallium(III) for Potential Antibacterial Applications |
| title_sort | exploring the co crystallization of kojic acid with silver i copper ii zinc ii and gallium iii for potential antibacterial applications |
| topic | antimicrobials antimicrobial metals silver copper gallium zinc |
| url | https://www.mdpi.com/1420-3049/28/3/1244 |
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