Bioprocess Development and Characterization of a <sup>13</sup>C-Labeled Hybrid Bispecific Antibody Produced in <i>Escherichia coli</i>

Bioprocess Development and Characterization of a <sup>13</sup>C-Labeled Hybrid Bispecific Antibody Produced in <i>Escherichia coli</i>

Monoclonal antibodies (mAbs) are highly efficacious therapeutics; however, due to their large, dynamic nature, structural perturbations and regional modifications are often difficult to study. Moreover, the homodimeric, symmetrical nature of mAbs makes it difficult to elucidate which heavy chain (HC...

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Bibliographic Details
Main Authors:	Aaron T. Wecksler, Victor Lundin, Ambrose J. Williams, Karthik Veeravalli, Dorothea E. Reilly, Sung-Hye Grieco
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Antibodies
Subjects:	biotherapeutic proteins protein isotopic labeling ambr250 bioreactors <sup>13</sup>C-celtone <sup>13</sup>C-labeled glucose knob-into-hole
Online Access:	https://www.mdpi.com/2073-4468/12/1/16

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