The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives
Ferroptosis is different from other forms of cell death, such as apoptosis, autophagy, pyroptosis, and cuproptosis, mainly involving iron metabolism and lipid peroxidation. Ferroptosis plays an important role in various disease, such as malignant tumors, neuron-degenerative diseases, and cardiovascu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/6/2125 |
| _version_ | 1797611048048525312 |
|---|---|
| author | Yunxiang Hu Yufei Wang Sanmao Liu Hong Wang |
| author_facet | Yunxiang Hu Yufei Wang Sanmao Liu Hong Wang |
| author_sort | Yunxiang Hu |
| collection | DOAJ |
| description | Ferroptosis is different from other forms of cell death, such as apoptosis, autophagy, pyroptosis, and cuproptosis, mainly involving iron metabolism and lipid peroxidation. Ferroptosis plays an important role in various disease, such as malignant tumors, neuron-degenerative diseases, and cardiovascular diseases, and has become the focus of current research. Both iron overload and lipid peroxide accumulation contribute to the occurrence, development, and treatment of musculoskeletal diseases, such as osteoporosis, osteoarthritis, osteosarcoma, intervertebral disc degeneration, and spinal cord injury. For a better understanding of the potential roles ferroptosis may play in pathophysiology and treatment of common musculoskeletal disorders, this article briefly reviewed the relationship and possible mechanisms. Through an investigation of ferroptosis’ role in musculoskeletal diseases’ occurrence, development, and treatment, ferroptosis could offer new opportunities for clinical diagnosis and treatment. |
| first_indexed | 2024-03-11T06:23:22Z |
| format | Article |
| id | doaj.art-bf86e1ef9daf445fb4ae188e2836921d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:23:22Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-bf86e1ef9daf445fb4ae188e2836921d2023-11-17T11:48:27ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126212510.3390/jcm12062125The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and PerspectivesYunxiang Hu0Yufei Wang1Sanmao Liu2Hong Wang3Department of Orthopedics, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, No. 826, Southwestern Road, Shahekou District, Dalian 116021, ChinaSchool of Graduates, Dalian Medical University, No. 9, West Section of South Lvshun Road, Dalian 116044, ChinaDepartment of Orthopedics, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, No. 826, Southwestern Road, Shahekou District, Dalian 116021, ChinaDepartment of Orthopedics, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, No. 826, Southwestern Road, Shahekou District, Dalian 116021, ChinaFerroptosis is different from other forms of cell death, such as apoptosis, autophagy, pyroptosis, and cuproptosis, mainly involving iron metabolism and lipid peroxidation. Ferroptosis plays an important role in various disease, such as malignant tumors, neuron-degenerative diseases, and cardiovascular diseases, and has become the focus of current research. Both iron overload and lipid peroxide accumulation contribute to the occurrence, development, and treatment of musculoskeletal diseases, such as osteoporosis, osteoarthritis, osteosarcoma, intervertebral disc degeneration, and spinal cord injury. For a better understanding of the potential roles ferroptosis may play in pathophysiology and treatment of common musculoskeletal disorders, this article briefly reviewed the relationship and possible mechanisms. Through an investigation of ferroptosis’ role in musculoskeletal diseases’ occurrence, development, and treatment, ferroptosis could offer new opportunities for clinical diagnosis and treatment.https://www.mdpi.com/2077-0383/12/6/2125ferroptosisosteoporosisosteoarthritisosteosarcomaintervertebral disc degenerationspinal cord injury |
| spellingShingle | Yunxiang Hu Yufei Wang Sanmao Liu Hong Wang The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives Journal of Clinical Medicine ferroptosis osteoporosis osteoarthritis osteosarcoma intervertebral disc degeneration spinal cord injury |
| title | The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives |
| title_full | The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives |
| title_fullStr | The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives |
| title_full_unstemmed | The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives |
| title_short | The Potential Roles of Ferroptosis in Pathophysiology and Treatment of Musculoskeletal Diseases—Opportunities, Challenges, and Perspectives |
| title_sort | potential roles of ferroptosis in pathophysiology and treatment of musculoskeletal diseases opportunities challenges and perspectives |
| topic | ferroptosis osteoporosis osteoarthritis osteosarcoma intervertebral disc degeneration spinal cord injury |
| url | https://www.mdpi.com/2077-0383/12/6/2125 |
| work_keys_str_mv | AT yunxianghu thepotentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT yufeiwang thepotentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT sanmaoliu thepotentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT hongwang thepotentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT yunxianghu potentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT yufeiwang potentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT sanmaoliu potentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives AT hongwang potentialrolesofferroptosisinpathophysiologyandtreatmentofmusculoskeletaldiseasesopportunitieschallengesandperspectives |