The Controversial History of Hormone Replacement Therapy
The history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the first results of the Women’s Health...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/55/9/602 |
| _version_ | 1827844598675800064 |
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| author | Angelo Cagnacci Martina Venier |
| author_facet | Angelo Cagnacci Martina Venier |
| author_sort | Angelo Cagnacci |
| collection | DOAJ |
| description | The history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the first results of the Women’s Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, HRT use dropped. The negative results of the study received wide publicity, creating panic among some users and new guidance for doctors on prescribing HRT. The clear message from the media was that HRT had more risks than benefits for all women. In the following years, a reanalysis of the WHI trial was performed, and new studies showed that the use of HRT in younger women or in early postmenopausal women had a beneficial effect on the cardiovascular system, reducing coronary disease and all-cause mortality. Notwithstanding this, the public opinion on HRT has not changed yet, leading to important negative consequences for women’s health and quality of life. |
| first_indexed | 2024-03-12T08:44:13Z |
| format | Article |
| id | doaj.art-bf88041383eb42b98b062e926eb09c25 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T08:44:13Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-bf88041383eb42b98b062e926eb09c252023-09-02T16:31:20ZengMDPI AGMedicina1010-660X2019-09-0155960210.3390/medicina55090602medicina55090602The Controversial History of Hormone Replacement TherapyAngelo Cagnacci0Martina Venier1Obstetrics and Gynecology Unit, Azienda Sanitaria Universitaria Integrata di, 33100 Udine, ItalyObstetrics and Gynecology Unit, Azienda Sanitaria Universitaria Integrata di, 33100 Udine, ItalyThe history of hormone replacement therapy (HRT) started in the 1960s, with very high popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal conditions were started in the USA in the late 1990s. After the announcement of the first results of the Women’s Health Initiative (WHI) in 2002, which showed that HRT had more detrimental than beneficial effects, HRT use dropped. The negative results of the study received wide publicity, creating panic among some users and new guidance for doctors on prescribing HRT. The clear message from the media was that HRT had more risks than benefits for all women. In the following years, a reanalysis of the WHI trial was performed, and new studies showed that the use of HRT in younger women or in early postmenopausal women had a beneficial effect on the cardiovascular system, reducing coronary disease and all-cause mortality. Notwithstanding this, the public opinion on HRT has not changed yet, leading to important negative consequences for women’s health and quality of life.https://www.mdpi.com/1010-660X/55/9/602hormone replacement therapyosteoporosisbreast cancercardiovascular disease |
| spellingShingle | Angelo Cagnacci Martina Venier The Controversial History of Hormone Replacement Therapy Medicina hormone replacement therapy osteoporosis breast cancer cardiovascular disease |
| title | The Controversial History of Hormone Replacement Therapy |
| title_full | The Controversial History of Hormone Replacement Therapy |
| title_fullStr | The Controversial History of Hormone Replacement Therapy |
| title_full_unstemmed | The Controversial History of Hormone Replacement Therapy |
| title_short | The Controversial History of Hormone Replacement Therapy |
| title_sort | controversial history of hormone replacement therapy |
| topic | hormone replacement therapy osteoporosis breast cancer cardiovascular disease |
| url | https://www.mdpi.com/1010-660X/55/9/602 |
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