A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse
Gemella sanguinis is a gram-positive, facultatively anaerobic coccus bacterium that has rarely been reported as a cause of infective endocarditis. A 41-year-old male patient with mitral valve prolapse visited the outpatient clinic presenting with fever. Transthoracic echocardiography and transesopha...
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| Format: | Article |
| Language: | English |
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Korean Society of Clinical Microbiology
2022-12-01
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| Series: | Annals of Clinical Microbiology |
| Subjects: | |
| Online Access: | https://www.acm.or.kr/acm_22-018/ |
| _version_ | 1797813549687373824 |
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| author | Hyun Jin Kim Sungmin Kym Qute Choi |
| author_facet | Hyun Jin Kim Sungmin Kym Qute Choi |
| author_sort | Hyun Jin Kim |
| collection | DOAJ |
| description | Gemella sanguinis is a gram-positive, facultatively anaerobic coccus bacterium that has rarely been reported as a cause of infective endocarditis. A 41-year-old male patient with mitral valve prolapse visited the outpatient clinic presenting with fever. Transthoracic echocardiography and transesophageal echocardiography revealed myxomatous change and vegetation of the mitral valve. We isolated G. sanguinis from the patient’s blood, cultured it in both aerobic and anaerobic blood culture bottles, and identified it using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS; bioM.rieux, France) and 16s rRNA sequencing. The isolated G. sanguinis was highly susceptible to penicillin and vancomycin and intermediately susceptible to erythromycin, clindamycin, and levofloxacin. Following the American Heart Association recommendations, this highly penicillin-sensitive isolate was eradicated with ceftriaxone and gentamicin, and the patient recovered and was discharged. To the best of our knowledge, this is the first reported case in Korea where G. sanguinis, the causative agent of endocarditis, was identified using MALDI-TOF MS and 16s rRNA sequencing and was treated with only antibiotics and without surgical valve replacement.
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| first_indexed | 2024-03-13T07:54:23Z |
| format | Article |
| id | doaj.art-bf8a571203404b5d804fc03de6386681 |
| institution | Directory Open Access Journal |
| issn | 2288-0585 2288-6850 |
| language | English |
| last_indexed | 2024-03-13T07:54:23Z |
| publishDate | 2022-12-01 |
| publisher | Korean Society of Clinical Microbiology |
| record_format | Article |
| series | Annals of Clinical Microbiology |
| spelling | doaj.art-bf8a571203404b5d804fc03de63866812023-06-02T07:12:10ZengKorean Society of Clinical MicrobiologyAnnals of Clinical Microbiology2288-05852288-68502022-12-0125416316810.5145/ACM.2022.25.4.6A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve ProlapseHyun Jin Kim0Sungmin Kym1Qute Choi2Department of Laboratory Medicine, KoreaDivision of Infectious Diseases, Department of Internal Medicine, Chungnam National University Sejong Hospital, Sejong, KoreaDepartment of Laboratory Medicine, KoreaGemella sanguinis is a gram-positive, facultatively anaerobic coccus bacterium that has rarely been reported as a cause of infective endocarditis. A 41-year-old male patient with mitral valve prolapse visited the outpatient clinic presenting with fever. Transthoracic echocardiography and transesophageal echocardiography revealed myxomatous change and vegetation of the mitral valve. We isolated G. sanguinis from the patient’s blood, cultured it in both aerobic and anaerobic blood culture bottles, and identified it using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS; bioM.rieux, France) and 16s rRNA sequencing. The isolated G. sanguinis was highly susceptible to penicillin and vancomycin and intermediately susceptible to erythromycin, clindamycin, and levofloxacin. Following the American Heart Association recommendations, this highly penicillin-sensitive isolate was eradicated with ceftriaxone and gentamicin, and the patient recovered and was discharged. To the best of our knowledge, this is the first reported case in Korea where G. sanguinis, the causative agent of endocarditis, was identified using MALDI-TOF MS and 16s rRNA sequencing and was treated with only antibiotics and without surgical valve replacement. https://www.acm.or.kr/acm_22-018/gemella sanguinisinfectious endocarditismaldi-tof ms16s rrna sequencing |
| spellingShingle | Hyun Jin Kim Sungmin Kym Qute Choi A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse Annals of Clinical Microbiology gemella sanguinis infectious endocarditis maldi-tof ms 16s rrna sequencing |
| title | A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse |
| title_full | A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse |
| title_fullStr | A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse |
| title_full_unstemmed | A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse |
| title_short | A Case Report of Gemella sanguinis Isolated From Blood Cultures of a Patient With Mitral Valve Prolapse |
| title_sort | case report of gemella sanguinis isolated from blood cultures of a patient with mitral valve prolapse |
| topic | gemella sanguinis infectious endocarditis maldi-tof ms 16s rrna sequencing |
| url | https://www.acm.or.kr/acm_22-018/ |
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