Association of inflammatory markers with cerebral small vessel disease in community-based population
Abstract Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD). Methods A total of 3052 community-dwelling residents from the Poly-vasculaR Evaluation...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-022-02468-0 |
| _version_ | 1818194527871041536 |
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| author | Lingling Jiang Xueli Cai Dongxiao Yao Jing Jing Lerong Mei Yingying Yang Shan Li Aoming Jin Xia Meng Hao Li Tiemin Wei Yongjun Wang Yuesong Pan Yilong Wang |
| author_facet | Lingling Jiang Xueli Cai Dongxiao Yao Jing Jing Lerong Mei Yingying Yang Shan Li Aoming Jin Xia Meng Hao Li Tiemin Wei Yongjun Wang Yuesong Pan Yilong Wang |
| author_sort | Lingling Jiang |
| collection | DOAJ |
| description | Abstract Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD). Methods A total of 3052 community-dwelling residents from the Poly-vasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study were involved in this cross-sectional study. CSVD burden and imaging markers, including white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS), were assessed according to total CSVD burden score. The associations of NC, NLR and SII with CSVD and imaging markers were evaluated using logistic regression models. Furthermore, two-sample Mendelian randomization (MR) analysis was performed to investigate the genetically predicted effect of NC on CSVD. The prognostic performances of NC, NLR and SII for the presence of CSVD were assessed. Results At baseline, the mean age was 61.2 ± 6.7 years, and 53.5% of the participants were female. Higher NC was suggestively associated with increased total CSVD burden and modified total CSVD burden (Q4 vs. Q1: common odds ratio (cOR) 1.33, 95% CI 1.05–1.70; cOR 1.28, 95% CI 1.02–1.60) and marginally correlated with the presence of CSVD (OR 1.29, 95% CI 1.00–1.66). Furthermore, elevated NC was linked to a higher risk of lacune (OR 2.13, 95% CI 1.25–3.62) and moderate-to-severe BG-EPVS (OR 1.67, 95% CI 1.14–2.44). A greater NLR was related to moderate-to-severe BG-EPVS (OR 1.68, 95% CI 1.16–2.45). Individuals with a higher SII had an increased risk of modified WMH burden (OR 1.35, 95% CI 1.08–1.69) and moderate-to-severe BG-EPVS (OR 1.70, 95% CI 1.20–2.41). MR analysis showed that genetically predicted higher NC was associated with an increased risk of lacunar stroke (OR 1.20, 95% CI 1.04–1.39) and small vessel stroke (OR 1.21, 95% CI 1.06–1.38). The addition of NC to the basic model with traditional risk factors improved the predictive ability for the presence of CSVD, as validated by the net reclassification index and integrated discrimination index (all p < 0.05). Conclusions This community-based population study found a suggestive association between NC and CSVD, especially for BG-EPVS and lacune, and provided evidence supporting the prognostic significance of NC. |
| first_indexed | 2024-12-12T01:03:43Z |
| format | Article |
| id | doaj.art-bf8c8269b7ad4226a73c557dd92de365 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-12T01:03:43Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-bf8c8269b7ad4226a73c557dd92de3652022-12-22T00:43:38ZengBMCJournal of Neuroinflammation1742-20942022-05-0119111210.1186/s12974-022-02468-0Association of inflammatory markers with cerebral small vessel disease in community-based populationLingling Jiang0Xueli Cai1Dongxiao Yao2Jing Jing3Lerong Mei4Yingying Yang5Shan Li6Aoming Jin7Xia Meng8Hao Li9Tiemin Wei10Yongjun Wang11Yuesong Pan12Yilong Wang13Department of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Lishui Hospital, Zhejiang University School of MedicineDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityCerebrovascular Research Lab, Lishui Hospital, Zhejiang University School of MedicineDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityCerebrovascular Research Lab, Lishui Hospital, Zhejiang University School of MedicineDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Lishui Hospital, Zhejiang University School of MedicineDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background This study investigated the relationships of neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with cerebral small vessel disease (CSVD). Methods A total of 3052 community-dwelling residents from the Poly-vasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study were involved in this cross-sectional study. CSVD burden and imaging markers, including white matter hyperintensity (WMH), lacunes, cerebral microbleeds (CMBs) and enlarged perivascular spaces in basal ganglia (BG-EPVS), were assessed according to total CSVD burden score. The associations of NC, NLR and SII with CSVD and imaging markers were evaluated using logistic regression models. Furthermore, two-sample Mendelian randomization (MR) analysis was performed to investigate the genetically predicted effect of NC on CSVD. The prognostic performances of NC, NLR and SII for the presence of CSVD were assessed. Results At baseline, the mean age was 61.2 ± 6.7 years, and 53.5% of the participants were female. Higher NC was suggestively associated with increased total CSVD burden and modified total CSVD burden (Q4 vs. Q1: common odds ratio (cOR) 1.33, 95% CI 1.05–1.70; cOR 1.28, 95% CI 1.02–1.60) and marginally correlated with the presence of CSVD (OR 1.29, 95% CI 1.00–1.66). Furthermore, elevated NC was linked to a higher risk of lacune (OR 2.13, 95% CI 1.25–3.62) and moderate-to-severe BG-EPVS (OR 1.67, 95% CI 1.14–2.44). A greater NLR was related to moderate-to-severe BG-EPVS (OR 1.68, 95% CI 1.16–2.45). Individuals with a higher SII had an increased risk of modified WMH burden (OR 1.35, 95% CI 1.08–1.69) and moderate-to-severe BG-EPVS (OR 1.70, 95% CI 1.20–2.41). MR analysis showed that genetically predicted higher NC was associated with an increased risk of lacunar stroke (OR 1.20, 95% CI 1.04–1.39) and small vessel stroke (OR 1.21, 95% CI 1.06–1.38). The addition of NC to the basic model with traditional risk factors improved the predictive ability for the presence of CSVD, as validated by the net reclassification index and integrated discrimination index (all p < 0.05). Conclusions This community-based population study found a suggestive association between NC and CSVD, especially for BG-EPVS and lacune, and provided evidence supporting the prognostic significance of NC.https://doi.org/10.1186/s12974-022-02468-0Cerebral small vessel diseaseInflammationNeutrophil countNeutrophil–lymphocyte ratioSystemic immune-inflammation index |
| spellingShingle | Lingling Jiang Xueli Cai Dongxiao Yao Jing Jing Lerong Mei Yingying Yang Shan Li Aoming Jin Xia Meng Hao Li Tiemin Wei Yongjun Wang Yuesong Pan Yilong Wang Association of inflammatory markers with cerebral small vessel disease in community-based population Journal of Neuroinflammation Cerebral small vessel disease Inflammation Neutrophil count Neutrophil–lymphocyte ratio Systemic immune-inflammation index |
| title | Association of inflammatory markers with cerebral small vessel disease in community-based population |
| title_full | Association of inflammatory markers with cerebral small vessel disease in community-based population |
| title_fullStr | Association of inflammatory markers with cerebral small vessel disease in community-based population |
| title_full_unstemmed | Association of inflammatory markers with cerebral small vessel disease in community-based population |
| title_short | Association of inflammatory markers with cerebral small vessel disease in community-based population |
| title_sort | association of inflammatory markers with cerebral small vessel disease in community based population |
| topic | Cerebral small vessel disease Inflammation Neutrophil count Neutrophil–lymphocyte ratio Systemic immune-inflammation index |
| url | https://doi.org/10.1186/s12974-022-02468-0 |
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