Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer?
Bladder cancer is the fourth most common cancer for men and the eighth most common cancer for women. Transitional cell carcinoma is the most predominant histological type. Bladder cancer is highly chemosensitive. In metastatic setting the treatment is based on cisplatin chemotherapy regimens type MV...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-09-01
|
| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/33 |
| _version_ | 1797963104258097152 |
|---|---|
| author | Nabil Ismaili Sanaa Elmajjaoui Youssef Bensouda Rhizlane Belbaraka Halima Abahssain Wafa Allam Zouhour Fadoukhair Mohamed Mesmoudi Rachid Tanz Tarik Mahfoud Abdelhamid Elomrani Mouna Khouchani Yassir Sbitti Noureddine Benjaafar Hassan Errihani Ali Tahri |
| author_facet | Nabil Ismaili Sanaa Elmajjaoui Youssef Bensouda Rhizlane Belbaraka Halima Abahssain Wafa Allam Zouhour Fadoukhair Mohamed Mesmoudi Rachid Tanz Tarik Mahfoud Abdelhamid Elomrani Mouna Khouchani Yassir Sbitti Noureddine Benjaafar Hassan Errihani Ali Tahri |
| author_sort | Nabil Ismaili |
| collection | DOAJ |
| description | Bladder cancer is the fourth most common cancer for men and the eighth most common cancer for women. Transitional cell carcinoma is the most predominant histological type. Bladder cancer is highly chemosensitive. In metastatic setting the treatment is based on cisplatin chemotherapy regimens type MVAC, MVAC-HD or gemcitabine plus cisplatin. The standard treatment of muscle invasive operable bladder cancer (T2–T4) used widely was radical cystectomy with pelvic lymph nodes dissection; the anatomical extent of pelvic lymphadenectomy has not accurately been defined so far. However, in the last decade, the treatment of tumors was improved by the introduction of chemotherapy as part of the management of the disease. Neoadjuvant chemotherapy should be considered at first, as standard treatment of choice, before local treatment for patients with good performance status (0–1) and good renal function–glomerular filtration rate (GFR) >60 mL/min. For patients treated with primary surgery, adjuvant chemotherapy is a valuable option in the case of lymph nodes involvement. This brief review would provide the evidence of the role of neoadjuvant chemotherapy in the management of operable muscle invasive (T2–T4) bladder cancer. |
| first_indexed | 2024-04-11T01:23:06Z |
| format | Article |
| id | doaj.art-bf8cbf38a3a046b3be9e33ce7dc12442 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:23:06Z |
| publishDate | 2011-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-bf8cbf38a3a046b3be9e33ce7dc124422023-01-03T10:55:35ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-09-015310.4081/oncol.2011.18528Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer?Nabil Ismaili0Sanaa Elmajjaoui1Youssef Bensouda2Rhizlane Belbaraka3Halima Abahssain4Wafa Allam5Zouhour Fadoukhair6Mohamed Mesmoudi7Rachid Tanz8Tarik Mahfoud9Abdelhamid Elomrani10Mouna Khouchani11Yassir Sbitti12Noureddine Benjaafar13Hassan Errihani14Ali Tahri15Centre d’oncologie, CHU Mohamed VI, MarrakechInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatCentre d’oncologie, CHU Mohamed VI, MarrakechInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatCentre d’oncologie, CHU Mohamed VI, MarrakechCentre d’oncologie, CHU Mohamed VI, MarrakechInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatInstitut National d’Oncologie, RabatCentre d’oncologie, CHU Mohamed VI, MarrakechBladder cancer is the fourth most common cancer for men and the eighth most common cancer for women. Transitional cell carcinoma is the most predominant histological type. Bladder cancer is highly chemosensitive. In metastatic setting the treatment is based on cisplatin chemotherapy regimens type MVAC, MVAC-HD or gemcitabine plus cisplatin. The standard treatment of muscle invasive operable bladder cancer (T2–T4) used widely was radical cystectomy with pelvic lymph nodes dissection; the anatomical extent of pelvic lymphadenectomy has not accurately been defined so far. However, in the last decade, the treatment of tumors was improved by the introduction of chemotherapy as part of the management of the disease. Neoadjuvant chemotherapy should be considered at first, as standard treatment of choice, before local treatment for patients with good performance status (0–1) and good renal function–glomerular filtration rate (GFR) >60 mL/min. For patients treated with primary surgery, adjuvant chemotherapy is a valuable option in the case of lymph nodes involvement. This brief review would provide the evidence of the role of neoadjuvant chemotherapy in the management of operable muscle invasive (T2–T4) bladder cancer.http://www.oncologyreviews.org/index.php/or/article/view/33Bladder cancer – Chemotherapy – Neoadjuvant chemotherapy – Adjuvant chemotherapy |
| spellingShingle | Nabil Ismaili Sanaa Elmajjaoui Youssef Bensouda Rhizlane Belbaraka Halima Abahssain Wafa Allam Zouhour Fadoukhair Mohamed Mesmoudi Rachid Tanz Tarik Mahfoud Abdelhamid Elomrani Mouna Khouchani Yassir Sbitti Noureddine Benjaafar Hassan Errihani Ali Tahri Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? Oncology Reviews Bladder cancer – Chemotherapy – Neoadjuvant chemotherapy – Adjuvant chemotherapy |
| title | Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? |
| title_full | Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? |
| title_fullStr | Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? |
| title_full_unstemmed | Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? |
| title_short | Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer? |
| title_sort | neoadjuvant or adjuvant chemotherapy what is the best treatment of muscle invasive bladder cancer |
| topic | Bladder cancer – Chemotherapy – Neoadjuvant chemotherapy – Adjuvant chemotherapy |
| url | http://www.oncologyreviews.org/index.php/or/article/view/33 |
| work_keys_str_mv | AT nabilismaili neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT sanaaelmajjaoui neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT youssefbensouda neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT rhizlanebelbaraka neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT halimaabahssain neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT wafaallam neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT zouhourfadoukhair neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT mohamedmesmoudi neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT rachidtanz neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT tarikmahfoud neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT abdelhamidelomrani neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT mounakhouchani neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT yassirsbitti neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT noureddinebenjaafar neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT hassanerrihani neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer AT alitahri neoadjuvantoradjuvantchemotherapywhatisthebesttreatmentofmuscleinvasivebladdercancer |