Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment–Drug Conjugates Carrying Maytansinoids DM1 and DM4

Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment–Drug Conjugates Carrying Maytansinoids DM1 and DM4

Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen. In a recent study, we generated pegylated monomers and multimers of scFv fra...

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Bibliographic Details
Main Authors: Daniel V. Kalinovsky, Irina V. Kholodenko, Elena V. Svirshchevskaya, Alexey V. Kibardin, Dmitry Yu. Ryazantsev, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Current Issues in Molecular Biology
Subjects:
antibody fragments
ganglioside GD2
pegylation
multimerization
maytansinoids
immunotherapy
Online Access:https://www.mdpi.com/1467-3045/45/10/512

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