A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study
Abstract Background The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12891-018-2055-1 |
| _version_ | 1819038467945922560 |
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| author | Kanichiro Wada Toshihiro Tanaka Gentaro Kumagai Hitoshi Kudo Toru Asari Daisuke Chiba Seiya Ota Keita Kamei On Takeda Shigeyuki Nakaji Yasuyuki Ishibashi |
| author_facet | Kanichiro Wada Toshihiro Tanaka Gentaro Kumagai Hitoshi Kudo Toru Asari Daisuke Chiba Seiya Ota Keita Kamei On Takeda Shigeyuki Nakaji Yasuyuki Ishibashi |
| author_sort | Kanichiro Wada |
| collection | DOAJ |
| description | Abstract Background The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. Methods Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project. We measured anteroposterior diameters at the levels of the cervical spinal disc in mid sagittal plane magnetic resonance imaging and evaluated disc degeneration. Spearman correlation coefficient was used to evaluate whether the diameters were correlated with disc degenerative scores. Stepwise multiple linear regression analysis was conducted with the score of disc degeneration as the dependent variable; and age, physical measurement values, bone mineral density of the forearm, and the value of serum bone metabolic markers and amino acids as the independent variables for each sex. Results As the age increased, the anteroposterior diameters decreased in both sexes. The minimum anteroposterior diameters were correlated with the disc degenerative scores (Spearman r = − 0.59, p < 0.001 in men, Spearman r = − 0.53, p < 0.001 in women). In multiple linear regression analysis, age, cross-linked N-telopeptide of type 1 collagen and isoleucine were significantly correlated with the cervical disc degenerative score in men (R2 = 0.47), and age and lysine were significantly correlated with the degenerative score in women (R2 = 0.50). Conclusion The factors responsible for cervical disc degeneration differed between men and women. Whether modifying these significant factors is possible, or whether this intervention would contribute to prevention of disc degeneration requires future studies. |
| first_indexed | 2024-12-21T08:37:47Z |
| format | Article |
| id | doaj.art-bf90861c022049c1a5e8ff122e0720a2 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-21T08:37:47Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-bf90861c022049c1a5e8ff122e0720a22022-12-21T19:10:01ZengBMCBMC Musculoskeletal Disorders1471-24742018-05-0119111110.1186/s12891-018-2055-1A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional studyKanichiro Wada0Toshihiro Tanaka1Gentaro Kumagai2Hitoshi Kudo3Toru Asari4Daisuke Chiba5Seiya Ota6Keita Kamei7On Takeda8Shigeyuki Nakaji9Yasuyuki Ishibashi10Department of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineDepartment of Social Health, Hirosaki University Graduate School of MedicineDepartment of Orthopedic Surgery, Hirosaki University Graduate School of MedicineAbstract Background The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. Methods Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project. We measured anteroposterior diameters at the levels of the cervical spinal disc in mid sagittal plane magnetic resonance imaging and evaluated disc degeneration. Spearman correlation coefficient was used to evaluate whether the diameters were correlated with disc degenerative scores. Stepwise multiple linear regression analysis was conducted with the score of disc degeneration as the dependent variable; and age, physical measurement values, bone mineral density of the forearm, and the value of serum bone metabolic markers and amino acids as the independent variables for each sex. Results As the age increased, the anteroposterior diameters decreased in both sexes. The minimum anteroposterior diameters were correlated with the disc degenerative scores (Spearman r = − 0.59, p < 0.001 in men, Spearman r = − 0.53, p < 0.001 in women). In multiple linear regression analysis, age, cross-linked N-telopeptide of type 1 collagen and isoleucine were significantly correlated with the cervical disc degenerative score in men (R2 = 0.47), and age and lysine were significantly correlated with the degenerative score in women (R2 = 0.50). Conclusion The factors responsible for cervical disc degeneration differed between men and women. Whether modifying these significant factors is possible, or whether this intervention would contribute to prevention of disc degeneration requires future studies.http://link.springer.com/article/10.1186/s12891-018-2055-1Cervical spineDisc degenerationBone metabolismAmino acid |
| spellingShingle | Kanichiro Wada Toshihiro Tanaka Gentaro Kumagai Hitoshi Kudo Toru Asari Daisuke Chiba Seiya Ota Keita Kamei On Takeda Shigeyuki Nakaji Yasuyuki Ishibashi A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study BMC Musculoskeletal Disorders Cervical spine Disc degeneration Bone metabolism Amino acid |
| title | A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study |
| title_full | A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study |
| title_fullStr | A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study |
| title_full_unstemmed | A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study |
| title_short | A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study |
| title_sort | study of the factors associated with cervical spinal disc degeneration with a focus on bone metabolism and amino acids in the japanese population a cross sectional study |
| topic | Cervical spine Disc degeneration Bone metabolism Amino acid |
| url | http://link.springer.com/article/10.1186/s12891-018-2055-1 |
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