TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein

TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein

Background: Pyroptosis is a critical form of cell death during the development of chronic kidney disease (CKD). Tripartite motif 6 (TRIM6) is an E3-ubiquitin ligase that participates in the progression renal fibrosis (RF). The aim of this study was to investigate the roles of TRIM6 and Glutathione p...

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Bibliographic Details
Main Authors: Lin Liao, Pengyu Tao, Qiming Xu, Wenhao Chen, Jie Chen, Weiwei Liu, Wenrui Liu, Jing Hu, Jianrao Lu
Format: Article
Language:English
Published: IMR Press 2024-02-01
Series:Frontiers in Bioscience-Landmark
Subjects:
renal fibrosis
oxidative stress
pyroptosis
ubiquitination
tripartite motif containing proteins
Online Access:https://www.imrpress.com/journal/FBL/29/2/10.31083/j.fbl2902058

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