Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems

Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems

The aim of this article was to study the trans-epithelial absorption to reach the blood and to target the brain by axonal transport using nasal formulations with nanonized meloxicam (nano MEL spray) and its salt form known as meloxicam potassium monohydrate (MELP spray). The physicochemical properti...

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Bibliographic Details
Main Authors: Csilla Bartos, Rita Ambrus, Anita Kovács, Róbert Gáspár, Anita Sztojkov-Ivanov, Árpád Márki, Tamás Janáky, Ferenc Tömösi, Gábor Kecskeméti, Piroska Szabó-Révész
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
nanosized meloxicam
meloxicam potassium monohydrate
intranasal formulation
dissolution rate
in vitro diffusion
plasma drug-content
absolute bioavailability for brain
Online Access:http://www.mdpi.com/1420-3049/23/4/784

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