Effect of Hydroalcoholic Extract of Truffle (Terfezia Boudieri) on Serum Level of Thyroid Hormones in Male Rats
Background and Aim: Thyroid gland makes thyroxine (T4) and triiodothyronine (T3) hormones. These hormones are really effective in regulating and control of basal metabolism. The purpose of this study was to assess the effect of hydroalcoholic extract of Terfezia Boundary (TB) on the serum level of t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Arak Medical University
2020-01-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://jams.arakmu.ac.ir/article-1-6078-en.html |
| Summary: | Background and Aim: Thyroid gland makes thyroxine (T4) and triiodothyronine (T3) hormones. These hormones are really effective in regulating and control of basal metabolism. The purpose of this study was to assess the effect of hydroalcoholic extract of Terfezia Boundary (TB) on the serum level of thyroid hormones.
Methods & Materials: In this experimental study, 30 male Wistar rats (weighing 200±10 g) were selected and divided into five groups of 6 including control, sham (received normal saline) and three experimental groups received TB with 75, 150 and 300 mg/kg doses via intraperitoneal injection for 14 days. Samples from all groups were collected at the end of the 14th day directly from the heart to evaluate thyroid hormone. The data were statistically analyzed in SPSS v. 12.
Ethical Considerations: This study was approved by the Research Ethics Committee of Ardabil University of Medical Sciences (code: IR.ARUMS.REC.1396.48).
Results: The results of this study showed that the T3 and T4 levels in the experimental groups 2 (150 mg/kg) and 3 (300 mg/kg) increased significantly compared to the control group (P<0.001 and P<0.01, respectively). The Thyroid Stimulating Hormone (TSH) level in the experimental groups 1 (75 mg/kg), 2 (150 mg/kg) and 3 (300 mg/kg) decreased significantly compared to the control group (P<0.05, P<0.001, P<0.001, respectively).
Conclusion: Hydroalcoholic extract of TB can increase the serum levels of thyroid hormones and reduce TSH level. |
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| ISSN: | 1735-5338 2008-644X |