The use of a single pass albumin dialysis for the management of liver failure
Introduction. A single pass albumin dialysis (SPAD) is a form of extracorporeal liver support system for removing albumin-bound toxins and water-soluble substances that accumulate in liver failure (LF). Case report. We presented three patients hospitalized for LF and treated using the SPAD at the Un...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2022-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100027A.pdf |
| _version_ | 1811183623889485824 |
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| author | Azaševac Tijana Knežević Violeta Ćelić Dejan Ljubičić Bojana Lakić Tanja Mitić Igor |
| author_facet | Azaševac Tijana Knežević Violeta Ćelić Dejan Ljubičić Bojana Lakić Tanja Mitić Igor |
| author_sort | Azaševac Tijana |
| collection | DOAJ |
| description | Introduction. A single pass albumin dialysis (SPAD) is a form of extracorporeal liver support system for removing albumin-bound toxins and water-soluble substances that accumulate in liver failure (LF). Case report. We presented three patients hospitalized for LF and treated using the SPAD at the University Clinical Center of Vojvodina, Serbia, from 2018 to 2019. Two of the patients presented with acute LF and one with acute-on-chronic LF. A total of 6 SPAD sessions were performed on each patient, resulting in decreased serum bilirubin and bile acid levels and hepatic encephalopathy grade. On discharge from the hospital, the liver function was improved in all the patients. Conclusion. SPAD removes the hepatotoxic substances without improvement of synthetic liver function. It represents a supportive treatment for LF patients who do not respond to the standard of care, offering a longer time for bridging to organ transplantation or spontaneous recovery of the liver function. |
| first_indexed | 2024-04-11T09:48:58Z |
| format | Article |
| id | doaj.art-bf92350171af401a8a9f1b43b7bf1b06 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-11T09:48:58Z |
| publishDate | 2022-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-bf92350171af401a8a9f1b43b7bf1b062022-12-22T04:30:52ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202022-01-0179882082410.2298/VSP201116027A0042-84502100027AThe use of a single pass albumin dialysis for the management of liver failureAzaševac Tijana0Knežević Violeta1Ćelić Dejan2Ljubičić Bojana3https://orcid.org/0000-0001-8317-6156Lakić Tanja4https://orcid.org/0000-0003-4246-5132Mitić Igor5University Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Department of Emergency Internal Medicine, Emergency Center, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + University Clinical Center of Vojvodina, Department of Pathology and Histology, Novi Sad, SerbiaUniversity Clinical Center of Vojvodina, Clinic for Nephrology and Clinical Immunology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaIntroduction. A single pass albumin dialysis (SPAD) is a form of extracorporeal liver support system for removing albumin-bound toxins and water-soluble substances that accumulate in liver failure (LF). Case report. We presented three patients hospitalized for LF and treated using the SPAD at the University Clinical Center of Vojvodina, Serbia, from 2018 to 2019. Two of the patients presented with acute LF and one with acute-on-chronic LF. A total of 6 SPAD sessions were performed on each patient, resulting in decreased serum bilirubin and bile acid levels and hepatic encephalopathy grade. On discharge from the hospital, the liver function was improved in all the patients. Conclusion. SPAD removes the hepatotoxic substances without improvement of synthetic liver function. It represents a supportive treatment for LF patients who do not respond to the standard of care, offering a longer time for bridging to organ transplantation or spontaneous recovery of the liver function.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100027A.pdfalbuminsliver failure, acuteregenerationrenal dialysistreatment outcome |
| spellingShingle | Azaševac Tijana Knežević Violeta Ćelić Dejan Ljubičić Bojana Lakić Tanja Mitić Igor The use of a single pass albumin dialysis for the management of liver failure Vojnosanitetski Pregled albumins liver failure, acute regeneration renal dialysis treatment outcome |
| title | The use of a single pass albumin dialysis for the management of liver failure |
| title_full | The use of a single pass albumin dialysis for the management of liver failure |
| title_fullStr | The use of a single pass albumin dialysis for the management of liver failure |
| title_full_unstemmed | The use of a single pass albumin dialysis for the management of liver failure |
| title_short | The use of a single pass albumin dialysis for the management of liver failure |
| title_sort | use of a single pass albumin dialysis for the management of liver failure |
| topic | albumins liver failure, acute regeneration renal dialysis treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100027A.pdf |
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