Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug‐Target Mendelian Randomization Study

Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug‐Target Mendelian Randomization Study

Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important therapeutic options for reducing cardiovascular disease risk; however, questions remain regarding potential differences in the neuropsychiatric impact of long‐term PCSK9 inhibition between men and women. Method...

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Bibliographic Details
Main Authors: Andrew S. Bell, Daniel B. Rosoff, Lucas A. Mavromatis, Jeesun Jung, Josephin Wagner, Falk W. Lohoff
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Alzheimer disease
cholesterol
cognition
dementia
depression
low‐density lipoprotein
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.026122

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.122.026122

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