Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Abstract The two main histopathological hallmarks that characterize Alzheimer’s Disease are the presence of amyloid plaques and neurofibrillary tangles. One of the current approaches to studying the consequences of amyloid pathology relies on the usage of transgenic animal models that incorporate th...

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Bibliographic Details
Main Authors: S. Tok, H. Maurin, C. Delay, D. Crauwels, N. V. Manyakov, W. Van Der Elst, D. Moechars, W. H. I. M. Drinkenburg
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-022-01393-w

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