Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine
Abstract Background Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes isolated in Regional Health Care Network 13 (RRAS 13), which include...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-08-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2696-y |
| _version_ | 1818038705481318400 |
|---|---|
| author | Marta Inês Cazentini Medeiros Samanta Cristine Grassi Almeida Maria Luiza Leopoldo Silva Guerra Paulo da Silva Ana Maria Machado Carneiro Denise de Andrade |
| author_facet | Marta Inês Cazentini Medeiros Samanta Cristine Grassi Almeida Maria Luiza Leopoldo Silva Guerra Paulo da Silva Ana Maria Machado Carneiro Denise de Andrade |
| author_sort | Marta Inês Cazentini Medeiros |
| collection | DOAJ |
| description | Abstract Background Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes isolated in Regional Health Care Network 13 (RRAS 13), which includes the regional health departments (RHDs) of Araraquara, Barretos, Franca and Ribeirão Preto, especially after the introduction of 10-valent pneumococcal conjugate vaccine (PCV10) in 2010. Methods The analyzed Spn strains were isolated from patients with invasive pneumococcal diseases (IPDs) and then sent to Adolfo Lutz Institute (ALI) for further confirmative identification tests during the period from 1998 to 2013. The samples were from the cities in RRAS13, which is located in the Northeast region of São Paulo State, and totals 90 municipalities. Results We analyzed strains isolated from 796 patients. They were predominantly: men (58.9%); 20 to 60 years old (32.2%); evaluated from 2003 to 2010 (60.2%); and diagnosed with meningitis (45.7%) and pneumonia (45.0%), the most common invasive pneumococcal diseases. In 2010, serotypes 3, 19F, 1, 23F, 6A and 6B were among the most frequent, while serotypes 3, 12F, 14, 6A, 18C, 8 and 6B were more common after the introduction of PCV10. Serotypes 14, 19F and 3 were more frequent in meningitis, while serotypes 14, 3 and 1 prevailed in pneumonia. After 2010, there was a decrease in serotypes 14, 1, 23F and 5 and an increase in serotypes 3, 12F, 11A and 8, which were not present in the vaccine. Conclusions The present study noted the increase in serotypes 3, 12F, 11A and 8 after vaccination. None of those serotypes are included in the available conjugate vaccines, which highlights the importance of continued monitoring of IPDs in order to measure the disease burden in the population in the long term and provide new epidemiological information to determine the impact of PCV10 in Brazil. |
| first_indexed | 2024-12-10T07:46:59Z |
| format | Article |
| id | doaj.art-bf9735e326ef4c5a94c70adc7b55a871 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-10T07:46:59Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-bf9735e326ef4c5a94c70adc7b55a8712022-12-22T01:57:10ZengBMCBMC Infectious Diseases1471-23342017-08-011711910.1186/s12879-017-2696-yDistribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccineMarta Inês Cazentini Medeiros0Samanta Cristine Grassi Almeida1Maria Luiza Leopoldo Silva Guerra2Paulo da Silva3Ana Maria Machado Carneiro4Denise de Andrade5Regional Laboratory Center of Instituto Adolfo Lutz - Ribeirão Preto and student at College of Nursing at University of São Paulo - Ribeirão PretoBacteriologic Center of Instituto Adolfo Lutz Central–São PauloBacteriologic Center of Instituto Adolfo Lutz Central–São PauloRegional Laboratory Center of Instituto Adolfo Lutz - Ribeirão PretoRegional Laboratory Center of Instituto Adolfo Lutz - Ribeirão PretoRibeirão Preto College of Nursing at University of São Paulo - Ribeirão PretoAbstract Background Infections caused by Streptococcus pneumoniae (Spn) still challenge health systems around the world, even with advances in vaccination programs. The present study evaluated the frequency of various Spn serotypes isolated in Regional Health Care Network 13 (RRAS 13), which includes the regional health departments (RHDs) of Araraquara, Barretos, Franca and Ribeirão Preto, especially after the introduction of 10-valent pneumococcal conjugate vaccine (PCV10) in 2010. Methods The analyzed Spn strains were isolated from patients with invasive pneumococcal diseases (IPDs) and then sent to Adolfo Lutz Institute (ALI) for further confirmative identification tests during the period from 1998 to 2013. The samples were from the cities in RRAS13, which is located in the Northeast region of São Paulo State, and totals 90 municipalities. Results We analyzed strains isolated from 796 patients. They were predominantly: men (58.9%); 20 to 60 years old (32.2%); evaluated from 2003 to 2010 (60.2%); and diagnosed with meningitis (45.7%) and pneumonia (45.0%), the most common invasive pneumococcal diseases. In 2010, serotypes 3, 19F, 1, 23F, 6A and 6B were among the most frequent, while serotypes 3, 12F, 14, 6A, 18C, 8 and 6B were more common after the introduction of PCV10. Serotypes 14, 19F and 3 were more frequent in meningitis, while serotypes 14, 3 and 1 prevailed in pneumonia. After 2010, there was a decrease in serotypes 14, 1, 23F and 5 and an increase in serotypes 3, 12F, 11A and 8, which were not present in the vaccine. Conclusions The present study noted the increase in serotypes 3, 12F, 11A and 8 after vaccination. None of those serotypes are included in the available conjugate vaccines, which highlights the importance of continued monitoring of IPDs in order to measure the disease burden in the population in the long term and provide new epidemiological information to determine the impact of PCV10 in Brazil.http://link.springer.com/article/10.1186/s12879-017-2696-yStreptococcus pneumoniaepneumococcusserotypeconjugate vaccine |
| spellingShingle | Marta Inês Cazentini Medeiros Samanta Cristine Grassi Almeida Maria Luiza Leopoldo Silva Guerra Paulo da Silva Ana Maria Machado Carneiro Denise de Andrade Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine BMC Infectious Diseases Streptococcus pneumoniae pneumococcus serotype conjugate vaccine |
| title | Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine |
| title_full | Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine |
| title_fullStr | Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine |
| title_full_unstemmed | Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine |
| title_short | Distribution of Streptococcus pneumoniae serotypes in the northeast macro-region of São Paulo state/Brazil after the introduction of conjugate vaccine |
| title_sort | distribution of streptococcus pneumoniae serotypes in the northeast macro region of sao paulo state brazil after the introduction of conjugate vaccine |
| topic | Streptococcus pneumoniae pneumococcus serotype conjugate vaccine |
| url | http://link.springer.com/article/10.1186/s12879-017-2696-y |
| work_keys_str_mv | AT martainescazentinimedeiros distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine AT samantacristinegrassialmeida distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine AT marialuizaleopoldosilvaguerra distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine AT paulodasilva distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine AT anamariamachadocarneiro distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine AT denisedeandrade distributionofstreptococcuspneumoniaeserotypesinthenortheastmacroregionofsaopaulostatebrazilaftertheintroductionofconjugatevaccine |